Implementation of a European regulation for cosmetics is the next logical step to enhance harmonization of cosmetic legislation in the European Union. However, the regulation of cosmetics alone will not be able to cure all deficits owing to different enforcement approaches in the Member States and deficiencies in cooperation. The regulation for cosmetics sets new standards that have to be fulfilled in practical work. Especially for a federal state like Germany, further harmonization with centralized reporting systems and transboundary cooperation is a great challenge. Some examples of such challenges for the Member States and Germany are addressed.