A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model

Amela Trbakovic; Patricia Hedenqvist; Torbjörn Mellgren; Cecilia Ley; Jöns Hilborn; Dmitri Ossipov; Stina Ekman; Carina B Johansson; Marianne Jensen-Waern; Andreas Thor

doi:10.1016/j.jdent.2017.12.009

A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model

J Dent. 2018 Mar:70:31-39. doi: 10.1016/j.jdent.2017.12.009. Epub 2017 Dec 16.

Authors

Affiliations

¹ Department of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, 751 85 Uppsala, Sweden. Electronic address: amela.trbakovic@surgsci.uu.se.
² Swedish University of Agricultural Sciences, Department of Clinical Sciences, PO Box 7054, 750 07 Uppsala, Sweden. Electronic address: patricia.hedenqvist@slu.se.
³ Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden. Electronic address: torbjorn.mellgren@angstrom.uu.se.
⁴ Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, PO Box 7028, 750 07 Uppsala, Sweden. Electronic address: cecilia.ley@slu.se.
⁵ Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden. Electronic address: jons.hilborn@kemi.uu.se.
⁶ Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden.
⁷ Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, PO Box 7028, 750 07 Uppsala, Sweden. Electronic address: stina.ekman@slu.se.
⁸ University of Gothenburg, The Sahlgrenska Academy, Institute of Odontology, Department of Prosthodontics, Dental Materials Science, P.O. Box 450, 405 30 Gothenburg, Sweden. Electronic address: carina.johansson@biomaterials.gu.se.
⁹ Swedish University of Agricultural Sciences, Department of Clinical Sciences, PO Box 7054, 750 07 Uppsala, Sweden. Electronic address: marianne.jensen-waern@slu.se.
¹⁰ Department of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, 751 85 Uppsala, Sweden. Electronic address: andreas.thor@akademiska.se.

PMID: 29258851
DOI: 10.1016/j.jdent.2017.12.009

Abstract

Objectives: The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid-calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model.

Material and methods: Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralateral side. In a sinus lift, the sinus mucosa was elevated and a titanium mini-implant was placed in the alveolar bone. Augmentation material (CPC, HABP·CaP or bovine bone) was applied in the space around the implant. The rabbits were euthanized three months after surgery and qualitative and histomorphometric evaluation were conducted. Histomorphometric evaluation included three different regions of interest (ROIs) and the bone to implant contact on each installed implant.

Results: Qualitative assessment (p = <.05), histomorphometric evaluations (p = < .01), and implant incorporation (p = <.05) showed that CPC and bovine mineral induced similar amount of bone and more than the HABP·CaP hydrogel.

Conclusion: CPC induced similar amount of bone as bovine mineral and both materials induced more bone than HABP·CaP hydrogel.

Clinical significance: The CPC is suggested as a synthetic alternative for augmentations in the maxillofacial area.

Keywords: Animal experiments; Bone implant interactions; Bone regeneration; Bone substitutes; Ceramic granules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alveolar Ridge Augmentation
Animals
Bone Regeneration* / drug effects
Bone Substitutes
Bone Transplantation*
Calcium Phosphates* / pharmacology
Cattle
Dental Implantation, Endosseous
Dental Implants
Male
Maxillary Sinus / pathology
Maxillary Sinus / surgery
Models, Animal
Nanoparticles / chemistry
Particle Size
Rabbits
Sinus Floor Augmentation*

Substances

Bone Substitutes
calcium phosphate
Calcium Phosphates
Dental Implants