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Year Number of Results
2018 3
2020 1
2022 2
2023 5
2024 3

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11 results

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Page 1
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice.
Pastor-Fernández A, Bertos AR, Sierra-Ramírez A, Del Moral-Salmoral J, Merino J, de Ávila AI, Olagüe C, Villares R, González-Aseguinolaza G, Rodríguez MÁ, Fresno M, Gironés N, Bustos M, Smerdou C, Fernandez-Marcos PJ, von Kobbe C. Pastor-Fernández A, et al. Aging Cell. 2023 Mar;22(3):e13771. doi: 10.1111/acel.13771. Epub 2023 Jan 26. Aging Cell. 2023. PMID: 36704839 Free PMC article.
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice.
Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Rodriguez-Ramiro I, et al. Among authors: pastor fernandez a. Free Radic Biol Med. 2024 Jan;210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. Epub 2023 Nov 29. Free Radic Biol Med. 2024. PMID: 38036067 Free article.
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Fernández AP, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. Ladds MJGW, et al. Among authors: fernandez ap. Nat Commun. 2023 Aug 18;14(1):5019. doi: 10.1038/s41467-023-40764-2. Nat Commun. 2023. PMID: 37596290 Free PMC article. No abstract available.
p21 is necessary for the beneficial effects of fasting during chemotherapy.
Plaza A, Pastor-Fernández A, López-Aceituno JL, Barradas M, Pantoja C, Fernandez-Marcos PJ. Plaza A, et al. Among authors: pastor fernandez a. Cancer Commun (Lond). 2023 Jan;43(1):164-168. doi: 10.1002/cac2.12384. Epub 2022 Nov 4. Cancer Commun (Lond). 2023. PMID: 36331275 Free PMC article. No abstract available.
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells.
Eriksen-Gjerstad M, Tveit Karlsen I, Fandalyuk Z, Benjaminsen S, Baran-Marszak F, Papp B, Locke F, Ladds M, Pastor-Fernández A, Gelebart P, Mc Cormack E. Eriksen-Gjerstad M, et al. Among authors: pastor fernandez a. EJHaem. 2022 May 15;3(3):913-918. doi: 10.1002/jha2.434. eCollection 2022 Aug. EJHaem. 2022. PMID: 36051066 Free PMC article.
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy.
Pastor-Fernández A, Gómez de Las Heras MM, Escrig-Larena JI, Barradas M, Pantoja C, Plaza A, Lopez-Aceituno JL, Durán E, Efeyan A, Mittelbrunn M, Martinez L, Fernandez-Marcos PJ. Pastor-Fernández A, et al. Cancer Commun (Lond). 2024 Apr;44(4):508-513. doi: 10.1002/cac2.12535. Epub 2024 Mar 21. Cancer Commun (Lond). 2024. PMID: 38512765 Free PMC article. No abstract available.
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
Ladds MJGW, Popova G, Pastor-Fernández A, Kannan S, van Leeuwen IMM, Håkansson M, Walse B, Tholander F, Bhatia R, Verma CS, Lane DP, Laín S. Ladds MJGW, et al. Among authors: pastor fernandez a. J Biol Chem. 2020 Dec 25;295(52):17935-17949. doi: 10.1074/jbc.RA119.012056. Epub 2020 Sep 8. J Biol Chem. 2020. PMID: 32900849 Free PMC article.
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. Ladds MJGW, et al. Among authors: pastor fernandez a. Nat Commun. 2018 Mar 16;9(1):1107. doi: 10.1038/s41467-018-03441-3. Nat Commun. 2018. PMID: 29549331 Free PMC article.
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.
Ladds MJGW, Pastor-Fernández A, Popova G, van Leeuwen IMM, Eng KE, Drummond CJ, Johansson L, Svensson R, Westwood NJ, McCarthy AR, Tholander F, Popa M, Lane DP, McCormack E, McInerney GM, Bhatia R, Laín S. Ladds MJGW, et al. Among authors: pastor fernandez a. PLoS One. 2018 Apr 23;13(4):e0195956. doi: 10.1371/journal.pone.0195956. eCollection 2018. PLoS One. 2018. PMID: 29684045 Free PMC article.
11 results