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Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
Ledneczki I, Némethy Z, Molnár KD, Tapolcsányi P, Ilkei V, Vágó I, Kolok S, Thán M, Laszy J, Balázs O, Krámos B, Szigetvári Á, Bata I, Makó A, Visegrády A, Fodor L, Vastag M, Lévay G, Lendvai B, Greiner I, Éles J. Ledneczki I, et al. Among authors: visegrady a. J Med Chem. 2023 Dec 14;66(23):16276-16302. doi: 10.1021/acs.jmedchem.3c01635. Epub 2023 Nov 21. J Med Chem. 2023. PMID: 37989278
Novel-Type GABAB PAMs: Structure-Activity Relationship in Light of the Protein Structure.
Krámos B, Hadady Z, Makó A, Szántó G, Felföldi N, Magdó I, Bobok AÁ, Bata I, Román V, Visegrády A, Keserű GM, Greiner I, Éles J. Krámos B, et al. Among authors: visegrady a. ACS Med Chem Lett. 2024 Mar 1;15(3):396-405. doi: 10.1021/acsmedchemlett.3c00560. eCollection 2024 Mar 14. ACS Med Chem Lett. 2024. PMID: 38505850
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
Ledneczki I, Tapolcsányi P, Gábor E, Visegrády A, Vass M, Éles J, Holm P, Horváth A, Pocsai A, Mahó S, Greiner I, Krámos B, Béni Z, Kóti J, Káncz AE, Thán M, Kolok S, Laszy J, Balázs O, Bugovits G, Nagy J, Vastag M, Szájli Á, Bozó É, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: visegrady a. Eur J Med Chem. 2021 Mar 15;214:113189. doi: 10.1016/j.ejmech.2021.113189. Epub 2021 Jan 14. Eur J Med Chem. 2021. PMID: 33540354
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Ledneczki I, Horváth A, Tapolcsányi P, Éles J, Molnár KD, Vágó I, Visegrády A, Kiss L, Szigetvári Á, Kóti J, Krámos B, Mahó S, Holm P, Kolok S, Fodor L, Thán M, Kostyalik D, Balázs O, Vastag M, Greiner I, Lévay G, Lendvai B, Némethy Z. Ledneczki I, et al. Among authors: visegrady a. Eur J Med Chem. 2021 Oct 15;222:113560. doi: 10.1016/j.ejmech.2021.113560. Epub 2021 May 29. Eur J Med Chem. 2021. PMID: 34111828
13 results