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Page 1
Showing results for anti ereg
Search for Andi Erega instead (3 results)
The Role of EREG/EGFR Pathway in Tumor Progression.
Cheng WL, Feng PH, Lee KY, Chen KY, Sun WL, Van Hiep N, Luo CS, Wu SM. Cheng WL, et al. Int J Mol Sci. 2021 Nov 27;22(23):12828. doi: 10.3390/ijms222312828. Int J Mol Sci. 2021. PMID: 34884633 Free PMC article. Review.
Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer progression. ...By contrast, the resistance of anti-EGFR therapy in CRC was driven by low EREG expression, aberrant genetic mutation and signal pathway alterations. …
Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer progression. ...By contrast, the resist …
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H. Li M, et al. Mol Cancer. 2022 Sep 19;21(1):181. doi: 10.1186/s12943-022-01654-1. Mol Cancer. 2022. PMID: 36117171 Free PMC article.
Further mechanistic studies have demonstrated that MIAC directly bind to AQP2 protein, inhibit EREG/EGFR expression and activate downstream pathways PI3K/AKT and MAPK to achieve anti-tumor effects. CONCLUSIONS: This study revealed for the first time the tumor suppre …
Further mechanistic studies have demonstrated that MIAC directly bind to AQP2 protein, inhibit EREG/EGFR expression and activate down …
Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway.
Wang Y, Chen L, Zhang M, Li X, Yang X, Huang T, Ban Y, Li Y, Li Q, Zheng Y, Sun Y, Wu J, Yu B. Wang Y, et al. Atherosclerosis. 2023 Jun;375:45-58. doi: 10.1016/j.atherosclerosis.2023.05.009. Epub 2023 May 11. Atherosclerosis. 2023. PMID: 37245426 Free article.
To explore the underlying mechanisms, mouse aortic endothelial cells (MAECs) were subjected to RNA-sequencing and CHIP-qPCR, which confirmed that Mecp2k271la repressed the expression of epiregulin (Ereg) by binding to its chromatin, demonstrating Ereg as a key downs …
To explore the underlying mechanisms, mouse aortic endothelial cells (MAECs) were subjected to RNA-sequencing and CHIP-qPCR, which confirmed …
Blocking EREG/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction.
Jehl A, Conrad O, Burgy M, Foppolo S, Vauchelles R, Ronzani C, Etienne-Selloum N, Chenard MP, Danic A, Dourlhes T, Thibault C, Schultz P, Dontenwill M, Martin S. Jehl A, et al. Cells. 2023 Feb 24;12(5):733. doi: 10.3390/cells12050733. Cells. 2023. PMID: 36899869 Free PMC article.
Its overexpression in HNSCC is correlated with short overall survival and progression-free survival but predictive of tumors responding to anti-EGFR therapies. Besides tumor cells, macrophages and cancer-associated fibroblasts shed EREG in the tumor microenvironment …
Its overexpression in HNSCC is correlated with short overall survival and progression-free survival but predictive of tumors responding to …
Integrated analysis of EREG expression, a gene associated with cervical cancer prognosis.
Yang S, Yang X, Li C. Yang S, et al. Am J Cancer Res. 2023 Oct 15;13(10):4644-4660. eCollection 2023. Am J Cancer Res. 2023. PMID: 37970371 Free PMC article.
Then, Survival analysis revealed that EREG was associated with the prognosis of CC and other tumor types, and high EREG expression was significantly associated with poor prognosis. ...EREG may be an independent prognostic marker for predicting tumor prognosis …
Then, Survival analysis revealed that EREG was associated with the prognosis of CC and other tumor types, and high EREG expres …
Potential biomarkers for anti-EGFR therapy in metastatic colorectal cancer.
Yang J, Li S, Wang B, Wu Y, Chen Z, Lv M, Lin Y, Yang J. Yang J, et al. Tumour Biol. 2016 Sep;37(9):11645-11655. doi: 10.1007/s13277-016-5140-9. Epub 2016 Jul 16. Tumour Biol. 2016. PMID: 27422777 Review.
Anti-epidermal growth factor receptor (EGFR) therapy has established efficacy in metastatic colorectal cancer, but a significant number of patients do not respond to such treatment. Recently, various biomarkers were reported to be useful in predicting resistance to anti …
Anti-epidermal growth factor receptor (EGFR) therapy has established efficacy in metastatic colorectal cancer, but a significant numb …
Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer.
Randon G, Pietrantonio F. Randon G, et al. Clin Cancer Res. 2023 Oct 13;29(20):4021-4023. doi: 10.1158/1078-0432.CCR-23-1954. Clin Cancer Res. 2023. PMID: 37594733 Free PMC article.
Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic colorectal cancer. High AREG/EREG may be coupled with negative hyper-selection (i.e., lack of genomic drivers of prim …
Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidednes …
Single-Cell Transcriptomics Reveals Crucial Cell Subsets and Functional Heterogeneity Associated With Carotid Atherosclerosis and Cerebrovascular Events.
Tan J, Liang Y, Yang Z, He Q, Tong J, Deng Y, Guo W, Liang K, Tang J, Shi W, Yu B. Tan J, et al. Arterioscler Thromb Vasc Biol. 2023 Dec;43(12):2312-2332. doi: 10.1161/ATVBAHA.123.318974. Epub 2023 Oct 26. Arterioscler Thromb Vasc Biol. 2023. PMID: 37881939 Free PMC article.
Two plaque-specific monocyte subsets performed diametrically opposed functions, EREG(+) monocytes promoted cerebrovascular events while C3(+) monocytes are anti-inflammatory. ...
Two plaque-specific monocyte subsets performed diametrically opposed functions, EREG(+) monocytes promoted cerebrovascular events whi …
Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer.
Williams CJM, Elliott F, Sapanara N, Aghaei F, Zhang L, Muranyi A, Yan D, Bai I, Zhao Z, Shires M, Wood HM, Richman SD, Hemmings G, Hale M, Bottomley D, Galvin L, Cartlidge C, Dance S, Bacon CM, Mansfield L, Young-Zvandasara K, Sudan A, Lambert K, Bibby I, Coupland SE, Montazeri A, Kipling N, Hughes K, Cross SS, Dewdney A, Pheasey L, Leng C, Gochera T, Mangham DC, Saunders M, Pritchard M, Stott H, Mukherjee A, Ilyas M, Silverman R, Hyland G, Sculthorpe D, Thornton K, Gould I, O'Callaghan A, Brown N, Turnbull S, Shaw L, Seymour MT, West NP, Seligmann JF, Singh S, Shanmugam K, Quirke P. Williams CJM, et al. Clin Cancer Res. 2023 Oct 13;29(20):4153-4165. doi: 10.1158/1078-0432.CCR-23-0859. Clin Cancer Res. 2023. PMID: 37363997 Free PMC article.
PURPOSE: High tumor production of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG), predicted benefit from anti-EGFR therapy for metastatic colorectal cancer (mCRC) in a retrospective analysis of clinical trial data. Here, AREG/EREG IHC was analyze …
PURPOSE: High tumor production of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG), predicted benefit from anti-EGF …
NONHSAT021545/miR-330-3p/EREG: A Cooperative Axis in Breast Cancer Prognosis and Treatment.
Zhang Y, Guo C, Yang S, Elkharti M, Liu R, Sun MZ, Liu S. Zhang Y, et al. J Clin Med. 2023 Mar 24;12(7):2478. doi: 10.3390/jcm12072478. J Clin Med. 2023. PMID: 37048561 Free PMC article.
Through data from TCGA and GEO database analysis, we speculated that miR-330-3p might be a tumor promoter, while EREG could be a tumor suppressor in BC. MiR-330-3p was upregulated, while lnc021545 and EREG were downregulated in 50 BC tissues. ...We finally discovere …
Through data from TCGA and GEO database analysis, we speculated that miR-330-3p might be a tumor promoter, while EREG could be a tumo …
81 results