Surface-Oxidized Polymer-Stabilized Silver Nanoparticles as a Covering Component of Suture Materials

Andrey Vladimirovich Blinov; Andrey Ashotovich Nagdalian; Sergey Nikolaevich Povetkin; Alexey Alekseevich Gvozdenko; Marina Nikolaevna Verevkina; Igor Vladimirovich Rzhepakovsky; Mariya Sergeevna Lopteva; David Guramievich Maglakelidze; Tatyana Semenovna Kataeva; Anastasiya Aleksandrovna Blinova; Alexey Borisovich Golik; Galina Vladimirovna Osipchuk; Mohammad Ali Shariati

doi:10.3390/mi13071105

Surface-Oxidized Polymer-Stabilized Silver Nanoparticles as a Covering Component of Suture Materials

Micromachines (Basel). 2022 Jul 14;13(7):1105. doi: 10.3390/mi13071105.

Authors

Andrey Vladimirovich Blinov¹, Andrey Ashotovich Nagdalian^{1

2}, Sergey Nikolaevich Povetkin¹, Alexey Alekseevich Gvozdenko¹, Marina Nikolaevna Verevkina³, Igor Vladimirovich Rzhepakovsky¹, Mariya Sergeevna Lopteva⁴, David Guramievich Maglakelidze¹, Tatyana Semenovna Kataeva⁵, Anastasiya Aleksandrovna Blinova¹, Alexey Borisovich Golik¹, Galina Vladimirovna Osipchuk⁶, Mohammad Ali Shariati⁷

Affiliations

¹ Department of Physics and Technology of Nanostructures and Materials, North Caucasus Federal University, 355017 Stavropol, Russia.
² Saint Petersburg State Agrarian University, 196601 Saint Petersburg, Russia.
³ Department of Parasitology and Veterinary Examination, Anatomy and Pathanatomy Named after Professor S. N. Nikolsky, Stavropol State Agrarian University, 355017 Stavropol, Russia.
⁴ Veterinary Medicine Laboratory of the Animal Husbandry, Veterinary Medicine Department, North Caucasus Federal Agrarian Research Centre, 356241 Mikhailovsk, Russia.
⁵ Department of Parasitology, Veterinary and Sanitary Expertise, Faculty of Veterinary Medicine, Kuban State Agrarian University Named after I. T. Trubilin, 350044 Krasnodar, Russia.
⁶ Laboratory of Embryos Reproduction and Transplantation, Scientific-Practical Institute of Biotechnologies in Animal Science and Veterinary Medicine, 249053 Maksimovka Village, Moldova.
⁷ Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia.

Abstract

In this work, we obtained silver nanoparticles stabilized with polyvinylpyrrolidone, ranging in size from 70 to 110 nm, which exhibits good crystallinity and anisotropic structure. For the first time, we studied the influence of the molar ratio of silver between silver and peroxide on the oxidation process of the nanoparticles and determined the regularities of this process by analyzing changes in absorption spectra. Our results showed that at molar ratios of Ag:H₂O₂ = 1:1 and 1:5, dependences of changes in the intensity, position and half-width of the absorption band of the plasmon resonance are rectilinear. In vivo studies of silver nanoparticles have shown that silver nanoparticles belong to the toxicity class III (moderately hazardous substance) and to the third group according to the degree of accumulation. We established that silver nanoparticles and oxidized silver nanoparticles form a uniform layer on the surface of the suture material. We found that the use of the suture material with silver nanoparticles and oxidized silver nanoparticles does not cause allergic reactions in the organisms of laboratory animals.

Keywords: oxidation; polyvinylpyrrolidone; silver nanoparticles; silver oxide nanoparticles; surface plasmon resonance; suture material.

Grants and funding

This research received no external funding.