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Page 1
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416.
Pharmaceutics. 2022.
PMID: 35890311
Free PMC article.
Molecular basis for hycanthone drug action in schistosome parasites.
Guzman M, Rugel A, Tarpley RS, Cao X, McHardy SF, LoVerde PT, Taylor AB.
Guzman M, et al. Among authors: rugel a.
Mol Biochem Parasitol. 2020 Mar;236:111257. doi: 10.1016/j.molbiopara.2020.111257. Epub 2020 Feb 3.
Mol Biochem Parasitol. 2020.
PMID: 32027942
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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT.
Rugel AR, et al.
Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10.
Int J Parasitol Drugs Drug Resist. 2020.
PMID: 32315953
Free PMC article.
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Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents.
Rugel A, Tarpley RS, Lopez A, Menard T, Guzman MA, Taylor AB, Cao X, Kovalskyy D, Chevalier FD, Anderson TJC, Hart PJ, LoVerde PT, McHardy SF.
Rugel A, et al.
ACS Med Chem Lett. 2018 Sep 14;9(10):967-973. doi: 10.1021/acsmedchemlett.8b00257. eCollection 2018 Oct 11.
ACS Med Chem Lett. 2018.
PMID: 30344901
Free PMC article.
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An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT.
Guzman MA, et al. Among authors: rugel ar.
PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug.
PLoS Negl Trop Dis. 2020.
PMID: 32810153
Free PMC article.
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Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine.
Taylor AB, Pica-Mattoccia L, Polcaro CM, Donati E, Cao X, Basso A, Guidi A, Rugel AR, Holloway SP, Anderson TJ, Hart PJ, Cioli D, LoVerde PT.
Taylor AB, et al. Among authors: rugel ar.
PLoS Negl Trop Dis. 2015 Oct 20;9(10):e0004132. doi: 10.1371/journal.pntd.0004132. eCollection 2015.
PLoS Negl Trop Dis. 2015.
PMID: 26485649
Free PMC article.
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Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.
Chevalier FD, Le Clec'h W, Eng N, Rugel AR, Assis RR, Oliveira G, Holloway SP, Cao X, Hart PJ, LoVerde PT, Anderson TJ.
Chevalier FD, et al. Among authors: rugel ar.
Int J Parasitol. 2016 Jun;46(7):417-24. doi: 10.1016/j.ijpara.2016.03.006. Epub 2016 Apr 9.
Int J Parasitol. 2016.
PMID: 27073078
Free PMC article.
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