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The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.
Lee SY, Munerol B, Pollard S, Youdim KA, Pannala AS, Kuhnle GG, Debnam ES, Rice-Evans C, Spencer JP. Lee SY, et al. Among authors: pannala as. Free Radic Biol Med. 2006 Jan 15;40(2):323-34. doi: 10.1016/j.freeradbiomed.2005.08.031. Epub 2005 Oct 11. Free Radic Biol Med. 2006. PMID: 16413414
Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations.
Nikam AN, Jacob A, Raychaudhuri R, Fernandes G, Pandey A, Rao V, Ahmad SF, Pannala AS, Mutalik S. Nikam AN, et al. Among authors: pannala as. Pharmaceutics. 2023 Aug 22;15(9):2175. doi: 10.3390/pharmaceutics15092175. Pharmaceutics. 2023. PMID: 37765146 Free PMC article.