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The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.
Spliid CB, Toledo AG, Sanderson P, Mao Y, Gatto F, Gustavsson T, Choudhary S, Saldanha AL, Vogelsang RP, Gögenur I, Theander TG, Leach FE 3rd, Amster IJ, Esko JD, Salanti A, Clausen TM. Spliid CB, et al. Among authors: saldanha al. J Biol Chem. 2021 Dec;297(6):101391. doi: 10.1016/j.jbc.2021.101391. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762909 Free PMC article.
Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis.
França-Costa J, Van Weyenbergh J, Boaventura VS, Luz NF, Malta-Santos H, Oliveira MC, Santos de Campos DC, Saldanha AC, dos-Santos WL, Bozza PT, Barral-Netto M, Barral A, Costa JM, Borges VM. França-Costa J, et al. Among authors: saldanha ac. J Infect Dis. 2015 Feb 1;211(3):426-35. doi: 10.1093/infdis/jiu455. Epub 2014 Aug 14. J Infect Dis. 2015. PMID: 25124926