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BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma.
Hipólito A, Xavier R, Brito C, Tomás A, Lemos I, Cabaço LC, Silva F, Oliva A, Barral DC, Vicente JB, Gonçalves LG, Pojo M, Serpa J. Hipólito A, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166983. doi: 10.1016/j.bbadis.2023.166983. Epub 2023 Dec 7. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38070581 Free article.
In this study, we disclosed BRD9 as a key regulator in cysteine metabolism and associated altered BRD9 to increased cell proliferation, migration and invasiveness, as well as to altered melanin levels, inducing higher susceptibility to melanomagenesis. It is evident that BRD9 WT …
In this study, we disclosed BRD9 as a key regulator in cysteine metabolism and associated altered BRD9 to increased cell proliferation, migr …