Amy S. T. Tong - Search Results

Year	Number of Results
2017	2
2018	1
2019	3
2020	3
2021	1
2022	2
2024	0

1

Synthesis and Structure-Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines.

Sutherland HS, Choi PJ, Lu GL, Giddens AC, Tong AST, Franzblau SG, Cooper CB, Palmer BD, Denny WA. Sutherland HS, et al. Among authors: tong ast. Pharmaceuticals (Basel). 2022 Sep 8;15(9):1125. doi: 10.3390/ph15091125. Pharmaceuticals (Basel). 2022. PMID: 36145345 Free PMC article.

2

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis.

Lu GL, Tong AST, Conole D, Sutherland HS, Choi PJ, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Denny WA, Palmer BD. Lu GL, et al. Among authors: tong ast. Bioorg Med Chem. 2020 Nov 15;28(22):115784. doi: 10.1016/j.bmc.2020.115784. Epub 2020 Sep 24. Bioorg Med Chem. 2020. PMID: 33007562 Free PMC article.

3

Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.

Sutherland HS, Lu GL, Tong AST, Conole D, Franzblau SG, Upton AM, Lotlikar MU, Cooper CB, Palmer BD, Choi PJ, Denny WA. Sutherland HS, et al. Among authors: tong ast. Eur J Med Chem. 2022 Feb 5;229:114059. doi: 10.1016/j.ejmech.2021.114059. Epub 2021 Dec 21. Eur J Med Chem. 2022. PMID: 34963068 Free PMC article.

4

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.

Sutherland HS, Tong AST, Choi PJ, Blaser A, Franzblau SG, Cooper CB, Upton AM, Lotlikar M, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: tong ast. Bioorg Med Chem. 2020 Jan 1;28(1):115213. doi: 10.1016/j.bmc.2019.115213. Epub 2019 Nov 26. Bioorg Med Chem. 2020. PMID: 31810890

5

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.

Blaser A, Sutherland HS, Tong AST, Choi PJ, Conole D, Franzblau SG, Cooper CB, Upton AM, Lotlikar M, Denny WA, Palmer BD. Blaser A, et al. Among authors: tong ast. Bioorg Med Chem. 2019 Apr 1;27(7):1283-1291. doi: 10.1016/j.bmc.2019.02.025. Epub 2019 Feb 15. Bioorg Med Chem. 2019. PMID: 30792104 Free PMC article.

6

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.

Choi PJ, Sutherland HS, Tong AST, Blaser A, Franzblau SG, Cooper CB, Lotlikar MU, Upton AM, Guillemont J, Motte M, Queguiner L, Andries K, Van den Broeck W, Denny WA, Palmer BD. Choi PJ, et al. Among authors: tong ast. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5190-5196. doi: 10.1016/j.bmcl.2017.10.042. Epub 2017 Oct 20. Bioorg Med Chem Lett. 2017. PMID: 29107541 Free PMC article.

7

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.

Sutherland HS, Tong AST, Choi PJ, Blaser A, Conole D, Franzblau SG, Lotlikar MU, Cooper CB, Upton AM, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: tong ast. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307. doi: 10.1016/j.bmc.2019.02.026. Epub 2019 Feb 15. Bioorg Med Chem. 2019. PMID: 30803745 Free PMC article.

8

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.

Sutherland HS, Tong AST, Choi PJ, Conole D, Blaser A, Franzblau SG, Cooper CB, Upton AM, Lotlikar MU, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: tong ast. Bioorg Med Chem. 2018 May 1;26(8):1797-1809. doi: 10.1016/j.bmc.2018.02.026. Epub 2018 Feb 20. Bioorg Med Chem. 2018. PMID: 29482950 Free PMC article.

9

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.

Tong AST, Choi PJ, Blaser A, Sutherland HS, Tsang SKY, Guillemont J, Motte M, Cooper CB, Andries K, Van den Broeck W, Franzblau SG, Upton AM, Denny WA, Palmer BD, Conole D. Tong AST, et al. ACS Med Chem Lett. 2017 Sep 22;8(10):1019-1024. doi: 10.1021/acsmedchemlett.7b00196. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057044 Free PMC article.

10

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline.

Choi PJ, Conole D, Sutherland HS, Blaser A, Tong AST, Cooper CB, Upton AM, Palmer BD, Denny WA. Choi PJ, et al. Among authors: tong ast. Molecules. 2020 Mar 20;25(6):1423. doi: 10.3390/molecules25061423. Molecules. 2020. PMID: 32245020 Free PMC article.

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