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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.
Mohammed HHH, Abd El-Hafeez AA, Ebeid K, Mekkawy AI, Abourehab MAS, Wafa EI, Alhaj-Suliman SO, Salem AK, Ghosh P, Abuo-Rahma GEA, Hayallah AM, Abbas SH. Mohammed HHH, et al. Among authors: mekkawy ai. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1346-1363. doi: 10.1080/14756366.2022.2072308. J Enzyme Inhib Med Chem. 2022. PMID: 35548854 Free PMC article.
The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated into PAMAM-coated PLGA-PEG nanoparticles.
Wiwatchaitawee K, Mekkawy AI, Quarterman JC, Naguib YW, Ebeid K, Geary SM, Salem AK. Wiwatchaitawee K, et al. Among authors: mekkawy ai. Drug Deliv Transl Res. 2022 Jul;12(7):1684-1696. doi: 10.1007/s13346-021-01065-7. Epub 2021 Oct 11. Drug Deliv Transl Res. 2022. PMID: 34635984 Free PMC article.
Injectable long-acting ivacaftor-loaded poly (lactide-co-glycolide) microparticle formulations for the treatment of cystic fibrosis: In vitro characterization and in vivo pharmacokinetics in mice.
Nakhla DS, Mekkawy AI, Naguib YW, Silva AD, Gao D, Ah Kim J, Alhaj-Suliman SO, Acri TM, Kumar Patel K, Ernst S, Stoltz DA, Welsh MJ, Salem AK. Nakhla DS, et al. Among authors: mekkawy ai. Int J Pharm. 2024 Jan 25;650:123693. doi: 10.1016/j.ijpharm.2023.123693. Epub 2023 Dec 9. Int J Pharm. 2024. PMID: 38081555 Free PMC article.