Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Molecules. 2015 Sep 2;20(9):16048-67. doi: 10.3390/molecules200916048.

Abstract

In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, ¹H-NMR, (13)C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.

Keywords: 1,2,4-triazole; 1,3,4-oxadiazole; 1,3,4-thiadiazole; Schiff base; antimicrobial activity; antitumor activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry*
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry*
  • Oxadiazoles / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • Schiff Bases / chemistry*
  • Thiadiazoles / chemistry*
  • Triazoles / chemistry*

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Oxadiazoles
  • Schiff Bases
  • Thiadiazoles
  • Triazoles
  • 1,3,4-thiadiazole
  • 1,3,4-oxadiazole
  • 1,2,4-triazole