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Page 1
The exerkine apelin reverses age-associated sarcopenia.
Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradère JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C. Vinel C, et al. Among authors: dortignac a. Nat Med. 2018 Sep;24(9):1360-1371. doi: 10.1038/s41591-018-0131-6. Epub 2018 Jul 30. Nat Med. 2018. PMID: 30061698 Clinical Trial.
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor.
Personnaz J, Piccolo E, Dortignac A, Iacovoni JS, Mariette J, Rocher V, Polizzi A, Batut A, Deleruyelle S, Bourdens L, Delos O, Combes-Soia L, Paccoud R, Moreau E, Martins F, Clouaire T, Benhamed F, Montagner A, Wahli W, Schwabe RF, Yart A, Castan-Laurell I, Bertrand-Michel J, Burlet-Schiltz O, Postic C, Denechaud PD, Moro C, Legube G, Lee CH, Guillou H, Valet P, Dray C, Pradère JP. Personnaz J, et al. Among authors: dortignac a. Sci Adv. 2022 Mar 25;8(12):eabg9055. doi: 10.1126/sciadv.abg9055. Epub 2022 Mar 25. Sci Adv. 2022. PMID: 35333579 Free PMC article.
Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation.
Valet C, Batut A, Vauclard A, Dortignac A, Bellio M, Payrastre B, Valet P, Severin S. Valet C, et al. Among authors: dortignac a. Cell Rep. 2020 Jul 7;32(1):107875. doi: 10.1016/j.celrep.2020.107875. Cell Rep. 2020. PMID: 32640240 Free article.
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations.
Paccoud R, Saint-Laurent C, Piccolo E, Tajan M, Dortignac A, Pereira O, Le Gonidec S, Baba I, Gélineau A, Askia H, Branchereau M, Charpentier J, Personnaz J, Branka S, Auriau J, Deleruyelle S, Canouil M, Beton N, Salles JP, Tauber M, Weill J, Froguel P, Neel BG, Araki T, Heymes C, Burcelin R, Castan I, Valet P, Dray C, Gautier EL, Edouard T, Pradère JP, Yart A. Paccoud R, et al. Among authors: dortignac a. Sci Transl Med. 2021 Apr 28;13(591):eabe2587. doi: 10.1126/scitranslmed.abe2587. Epub 2021 Apr 28. Sci Transl Med. 2021. PMID: 33910978
Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development.
Chaves-Almagro C, Auriau J, Dortignac A, Clerc P, Lulka H, Deleruyelle S, Projetti F, Nakhlé J, Frances A, Berta J, Gigoux V, Fourmy D, Dufresne M, Gomez-Brouchet A, Guillermet-Guibert J, Cordelier P, Knibiehler B, Jockers R, Valet P, Audigier Y, Masri B. Chaves-Almagro C, et al. Among authors: dortignac a. Int J Mol Sci. 2022 Sep 13;23(18):10600. doi: 10.3390/ijms231810600. Int J Mol Sci. 2022. PMID: 36142542 Free PMC article.
Apelin affects the mouse aging urinary peptidome with minimal effects on kidney.
Vinel C, Schanstra JP, Boizard F, Péreira O, Auriau J, Dortignac A, Breuil B, Feuillet G, Nkuipou-Kenfack E, Zürbig P, Valet P, Bascands JL, Dray C, Denis C. Vinel C, et al. Among authors: dortignac a. Sci Rep. 2019 Jul 23;9(1):10647. doi: 10.1038/s41598-019-47109-4. Sci Rep. 2019. PMID: 31337837 Free PMC article.
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.
Romier B, Dray C, Vanalderwiert L, Wahart A, Hocine T, Dortignac A, Garbar C, Garbar C, Boulagnon C, Bouland N, Maurice P, Bennasroune A, Sartelet H, Martiny L, Duca L, Valet P, Blaise S. Romier B, et al. Among authors: dortignac a. Sci Rep. 2021 Nov 15;11(1):22278. doi: 10.1038/s41598-021-01735-z. Sci Rep. 2021. PMID: 34782679 Free PMC article.