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Page 1
Replacement of the Mouse LD50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations.
Toxins (Basel). 2023 Apr 29;15(5):314. doi: 10.3390/toxins15050314.
Toxins (Basel). 2023.
PMID: 37235349
Free PMC article.
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues.
Phillips JJ, Buchanan A, Andrews J, Chodorge M, Sridharan S, Mitchell L, Burmeister N, Kippen AD, Vaughan TJ, Higazi DR, Lowe D.
Phillips JJ, et al. Among authors: kippen ad.
Anal Chem. 2017 Feb 21;89(4):2361-2368. doi: 10.1021/acs.analchem.6b04158. Epub 2017 Feb 3.
Anal Chem. 2017.
PMID: 28194941
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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC.
Dobson CL, et al. Among authors: kippen ad.
Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644.
Sci Rep. 2016.
PMID: 27995962
Free PMC article.
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Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.
Edgeworth MJ, Phillips JJ, Lowe DC, Kippen AD, Higazi DR, Scrivens JH.
Edgeworth MJ, et al. Among authors: kippen ad.
Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15156-9. doi: 10.1002/anie.201507223. Epub 2015 Oct 20.
Angew Chem Int Ed Engl. 2015.
PMID: 26482340
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Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.
Spooner J, Keen J, Nayyar K, Birkett N, Bond N, Bannister D, Tigue N, Higazi D, Kemp B, Vaughan T, Kippen A, Buchanan A.
Spooner J, et al. Among authors: kippen a.
Biotechnol Bioeng. 2015 Jul;112(7):1472-7. doi: 10.1002/bit.25550. Epub 2015 Mar 12.
Biotechnol Bioeng. 2015.
PMID: 25619171
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