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The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA.
Cell Death Discov. 2022 Apr 20;8(1):215. doi: 10.1038/s41420-022-01009-1.
Cell Death Discov. 2022.
PMID: 35443750
Free PMC article.
The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA.
Muenchow A, Weller S, Hinterleitner C, Malenke E, Bugl S, Wirths S, Müller MR, Schulze-Osthoff K, Aulitzky WE, Kopp HG, Essmann F.
Muenchow A, et al.
Cell Death Dis. 2020 Aug 24;11(8):701. doi: 10.1038/s41419-020-02910-2.
Cell Death Dis. 2020.
PMID: 32839432
Free PMC article.
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Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion.
Kosnopfel C, Sinnberg T, Sauer B, Niessner H, Muenchow A, Fehrenbacher B, Schaller M, Mertens PR, Garbe C, Thakur BK, Schittek B.
Kosnopfel C, et al. Among authors: muenchow a.
Cancers (Basel). 2020 Aug 18;12(8):2328. doi: 10.3390/cancers12082328.
Cancers (Basel). 2020.
PMID: 32824741
Free PMC article.
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