Efficient synthetic inhibitors of anthrax lethal factor.
Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M.
Forino M, et al.
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504. doi: 10.1073/pnas.0502733102. Epub 2005 Jun 27.
Proc Natl Acad Sci U S A. 2005.
PMID: 15983377
Free PMC article.
Initial in vivo evaluation of postexposure efficacy of our inhibitors combined with antibiotic ciprofloxacin against B. anthracis resulted in significant protection. Our data strongly indicate that the scaffold of inhibitors we have identified is the foundation for the dev …
Initial in vivo evaluation of postexposure efficacy of our inhibitors combined with antibiotic ciprofloxacin against B. anthracis res …