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Page 1
Strategies to Better Target Fungal Squalene Monooxygenase.
J Fungi (Basel). 2021 Jan 13;7(1):49. doi: 10.3390/jof7010049.
J Fungi (Basel). 2021.
PMID: 33450973
Free PMC article.
Review.
Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design.
Monk BC, Sagatova AA, Hosseini P, Ruma YN, Wilson RK, Keniya MV.
Monk BC, et al. Among authors: sagatova aa.
Biochim Biophys Acta Proteins Proteom. 2020 Mar;1868(3):140206. doi: 10.1016/j.bbapap.2019.02.008. Epub 2019 Mar 6.
Biochim Biophys Acta Proteins Proteom. 2020.
PMID: 30851431
Review.
Item in Clipboard
Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD.
Sagatova AA, et al.
Antimicrob Agents Chemother. 2015 Aug;59(8):4982-9. doi: 10.1128/AAC.00925-15. Epub 2015 Jun 8.
Antimicrob Agents Chemother. 2015.
PMID: 26055382
Free PMC article.
Item in Clipboard
Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.
Tyndall JD, Sabherwal M, Sagatova AA, Keniya MV, Negroni J, Wilson RK, Woods MA, Tietjen K, Monk BC.
Tyndall JD, et al. Among authors: sagatova aa.
PLoS One. 2016 Dec 1;11(12):e0167485. doi: 10.1371/journal.pone.0167485. eCollection 2016.
PLoS One. 2016.
PMID: 27907120
Free PMC article.
Item in Clipboard
Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase.
Sagatova AA, Keniya MV, Wilson RK, Sabherwal M, Tyndall JD, Monk BC.
Sagatova AA, et al.
Sci Rep. 2016 May 18;6:26213. doi: 10.1038/srep26213.
Sci Rep. 2016.
PMID: 27188873
Free PMC article.
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Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
Sagatova AA, Keniya MV, Tyndall JDA, Monk BC.
Sagatova AA, et al.
Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02242-17. doi: 10.1128/AAC.02242-17. Print 2018 Mar.
Antimicrob Agents Chemother. 2018.
PMID: 29263059
Free PMC article.
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Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
Keniya MV, Sabherwal M, Wilson RK, Woods MA, Sagatova AA, Tyndall JDA, Monk BC.
Keniya MV, et al. Among authors: sagatova aa.
Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01134-18. doi: 10.1128/AAC.01134-18. Print 2018 Nov.
Antimicrob Agents Chemother. 2018.
PMID: 30126961
Free PMC article.
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