SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.
Hanson JE, La H, Plise E, Chen YH, Ding X, Hanania T, Sabath EV, Alexandrov V, Brunner D, Leahy E, Steiner P, Liu L, Scearce-Levie K, Zhou Q.
Hanson JE, et al. Among authors: alexandrov v.
PLoS One. 2013 Jul 26;8(7):e69964. doi: 10.1371/journal.pone.0069964. Print 2013.
PLoS One. 2013.
PMID: 23922875
Free PMC article.
Thus while our in vitro data show that HDAC inhibition can enhance excitatory synaptic strength and potentiation, our in vivo data suggests limited brain availability may contribute to the lack of behavioral impact of SAHA following peripheral delivery. These results do no …
Thus while our in vitro data show that HDAC inhibition can enhance excitatory synaptic strength and potentiation, our in vivo data suggests …