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Mechanisms of APOBEC3 mutagenesis in human cancer cells.
Petljak M, Dananberg A, Chu K, Bergstrom EN, Striepen J, von Morgen P, Chen Y, Shah H, Sale JE, Alexandrov LB, Stratton MR, Maciejowski J. Petljak M, et al. Among authors: dananberg a. Nature. 2022 Jul;607(7920):799-807. doi: 10.1038/s41586-022-04972-y. Epub 2022 Jul 20. Nature. 2022. PMID: 35859169 Free PMC article.
An impaired ubiquitin-proteasome system increases APOBEC3A abundance.
Coxon M, Dennis MA, Dananberg A, Collins CD, Wilson HE, Meekma J, Savenkova MI, Ng D, Osbron CA, Mertz TM, Goodman AG, Duttke SH, Maciejowski J, Roberts SA. Coxon M, et al. Among authors: dananberg a. NAR Cancer. 2023 Dec 19;5(4):zcad058. doi: 10.1093/narcan/zcad058. eCollection 2023 Dec. NAR Cancer. 2023. PMID: 38155930 Free PMC article.
Intratumoral TREX1 induction promotes immune evasion by limiting type I interferon.
Toufektchan E, Dananberg A, Striepen J, Hickling JH, Shim A, Chen Y, Nichols A, Duran Paez MA, Mohr L, Bakhoum SF, Maciejowski J. Toufektchan E, et al. Among authors: dananberg a. Cancer Immunol Res. 2024 Feb 26. doi: 10.1158/2326-6066.CIR-23-1093. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38408184
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.
Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. Maciejowski J, et al. Among authors: dananberg a. Nat Genet. 2020 Sep;52(9):884-890. doi: 10.1038/s41588-020-0667-5. Epub 2020 Jul 27. Nat Genet. 2020. PMID: 32719516 Free PMC article.
Monitoring APOBEC3A protein levels in human cancer cells.
Dananberg A, Maciejowski J. Dananberg A, et al. Methods Cell Biol. 2024;182:313-327. doi: 10.1016/bs.mcb.2022.10.008. Epub 2022 Nov 18. Methods Cell Biol. 2024. PMID: 38359985 Free PMC article.