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Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.
Wang T, Gross C, Desai AA, Zemskov E, Wu X, Garcia AN, Jacobson JR, Yuan JX, Garcia JG, Black SM. Wang T, et al. Among authors: garcia an. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L452-L476. doi: 10.1152/ajplung.00231.2016. Epub 2016 Dec 15. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 27979857 Free PMC article. Review.
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization.
Garcia AN, Casanova NG, Valera DG, Sun X, Song JH, Kempf CL, Moreno-Vinasco L, Burns K, Bermudez T, Valdez M, Cuellar G, Gregory T, Oita RC, Hernon VR, Barber C, Camp SM, Martin D, Liu Z, Bime C, Sammani S, Cress AE, Garcia JG. Garcia AN, et al. Transl Res. 2022 Jan;239:44-57. doi: 10.1016/j.trsl.2021.06.002. Epub 2021 Jun 15. Transl Res. 2022. PMID: 34139379 Free PMC article.
eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling.
Bermudez T, Sammani S, Song JH, Hernon VR, Kempf CL, Garcia AN, Burt J, Hufford M, Camp SM, Cress AE, Desai AA, Natarajan V, Jacobson JR, Dudek SM, Cancio LC, Alvarez J, Rafikov R, Li Y, Zhang DD, Casanova NG, Bime C, Garcia JGN. Bermudez T, et al. Among authors: garcia an. Sci Rep. 2022 Jan 13;12(1):696. doi: 10.1038/s41598-021-04444-9. Sci Rep. 2022. PMID: 35027578 Free PMC article.
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis.
Garcia AN, Casanova NG, Kempf CL, Bermudez T, Valera DG, Song JH, Sun X, Cai H, Moreno-Vinasco L, Gregory T, Oita RC, Hernon VR, Camp SM, Rogers C, Kyubwa EM, Menon N, Axtelle J, Rappaport J, Bime C, Sammani S, Cress AE, Garcia JGN. Garcia AN, et al. Am J Respir Cell Mol Biol. 2022 May;66(5):497-509. doi: 10.1165/rcmb.2021-0357OC. Am J Respir Cell Mol Biol. 2022. PMID: 35167418 Free PMC article.
Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody.
Quijada H, Bermudez T, Kempf CL, Valera DG, Garcia AN, Camp SM, Song JH, Franco E, Burt JK, Sun B, Mascarenhas JB, Burns K, Gaber A, Oita RC, Reyes Hernon V, Barber C, Moreno-Vinasco L, Sun X, Cress AE, Martin D, Liu Z, Desai AA, Natarajan V, Jacobson JR, Dudek SM, Bime C, Sammani S, Garcia JGN. Quijada H, et al. Among authors: garcia an. Eur Respir J. 2021 May 6;57(5):2002536. doi: 10.1183/13993003.02536-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33243842 Free PMC article.