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Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential.
Pharmacol Res. 2022 Sep;183:106373. doi: 10.1016/j.phrs.2022.106373. Epub 2022 Jul 28.
Pharmacol Res. 2022.
PMID: 35907433
Review.
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model.
Pupyshev AB, Belichenko VM, Tenditnik MV, Bashirzade AA, Dubrovina NI, Ovsyukova MV, Akopyan AA, Fedoseeva LA, Korolenko TA, Amstislavskaya TG, Tikhonova MA.
Pupyshev AB, et al.
Pharmacol Biochem Behav. 2022 Jun;217:173406. doi: 10.1016/j.pbb.2022.173406. Epub 2022 May 21.
Pharmacol Biochem Behav. 2022.
PMID: 35609863
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Comparative analysis of early neurodegeneration signs in a mouse model of Alzheimer's disease-like pathology induced by two types of the central (Intracerebroventricular vs. Intrahippocampal) administration of Aβ25-35 oligomers.
Belichenko VM, Bashirzade AA, Tenditnik MV, Dubrovina NI, Akopyan AA, Ovsyukova MV, Fedoseeva LA, Pupyshev AB, Aftanas LI, Amstislavskaya TG, Tikhonova MA.
Belichenko VM, et al. Among authors: pupyshev ab.
Behav Brain Res. 2023 Oct 2;454:114651. doi: 10.1016/j.bbr.2023.114651. Epub 2023 Aug 30.
Behav Brain Res. 2023.
PMID: 37657512
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Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice.
Korolenko TA, Dubrovina NI, Ovsyukova MV, Bgatova NP, Tenditnik MV, Pupyshev AB, Akopyan AA, Goncharova NV, Lin CL, Zavjalov EL, Tikhonova MA, Amstislavskaya TG.
Korolenko TA, et al. Among authors: pupyshev ab.
Cells. 2021 Sep 27;10(10):2557. doi: 10.3390/cells10102557.
Cells. 2021.
PMID: 34685538
Free PMC article.
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Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression.
Pupyshev AB, Korolenko TA, Akopyan AA, Amstislavskaya TG, Tikhonova MA.
Pupyshev AB, et al.
Neurosci Lett. 2018 Apr 13;672:140-144. doi: 10.1016/j.neulet.2017.12.001. Epub 2017 Dec 2.
Neurosci Lett. 2018.
PMID: 29203207
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Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease.
Pupyshev AB, Tikhonova MA, Akopyan AA, Tenditnik MV, Dubrovina NI, Korolenko TA.
Pupyshev AB, et al.
Pharmacol Biochem Behav. 2019 Feb;177:1-11. doi: 10.1016/j.pbb.2018.12.005. Epub 2018 Dec 21.
Pharmacol Biochem Behav. 2019.
PMID: 30582934
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