One year in review 2018: systemic lupus erythematosus

Clin Exp Rheumatol. 2018 Sep-Oct;36(5):763-777. Epub 2018 Sep 26.

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune condition characterised by a wide spectrum of clinical manifestations, partly related to the disease itself, but also linked to its comorbidities and drugs adverse reactions. Following the previous annual reviews, we focused on new insights in SLE clinical features, pathogenic pathways, biomarkers of specific organ involvement and therapeutic strategies. We finally concentrated on SLE aspects that could significantly influence patients' quality of life and that need to be investigated in detail through the development and validation of disease-specific patient-reported outcomes.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Comorbidity
  • Disease Progression
  • Health Status
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Erythematosus, Systemic* / drug therapy
  • Lupus Erythematosus, Systemic* / epidemiology
  • Lupus Erythematosus, Systemic* / immunology
  • Predictive Value of Tests
  • Quality of Life
  • Risk Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • Immunosuppressive Agents