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An optimized SpCas9 high-fidelity variant for direct protein delivery.
Mol Ther. 2023 Jul 5;31(7):2257-2265. doi: 10.1016/j.ymthe.2023.03.007. Epub 2023 Mar 10.
Mol Ther. 2023.
PMID: 36905119
Free article.
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.
Zamboni V, Jones R, Umbach A, Ammoni A, Passafaro M, Hirsch E, Merlo GR.
Zamboni V, et al. Among authors: umbach a.
Int J Mol Sci. 2018 Jun 20;19(6):1821. doi: 10.3390/ijms19061821.
Int J Mol Sci. 2018.
PMID: 29925821
Free PMC article.
Review.
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Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology.
Umbach A, Maule G, Kheir E, Cutarelli A, Foglia M, Guarrera L, Fava LL, Conti L, Garattini E, Terao M, Cereseto A.
Umbach A, et al.
Stem Cell Res Ther. 2022 Sep 2;13(1):440. doi: 10.1186/s13287-022-03135-0.
Stem Cell Res Ther. 2022.
PMID: 36056433
Free PMC article.
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Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.
Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.
Zamboni V, et al. Among authors: umbach a.
Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.
Sci Rep. 2018.
PMID: 29740022
Free PMC article.
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Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia.
Villa C, Legato M, Umbach A, Riganti C, Jones R, Martini B, Boido M, Medana C, Facchinetti I, Barni D, Pinto M, Arguello T, Belicchi M, Fagiolari G, Liaci C, Moggio M, Ruffo R, Moraes CT, Monguzzi A, Merlo GR, Torrente Y.
Villa C, et al. Among authors: umbach a.
Sci Transl Med. 2021 Aug 18;13(607):eabe1633. doi: 10.1126/scitranslmed.abe1633.
Sci Transl Med. 2021.
PMID: 34408077
Free article.
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Choice of Alternative Polyadenylation Sites, Mediated by the RNA-Binding Protein Elavl3, Plays a Role in Differentiation of Inhibitory Neuronal Progenitors.
Grassi E, Santoro R, Umbach A, Grosso A, Oliviero S, Neri F, Conti L, Ala U, Provero P, DiCunto F, Merlo GR.
Grassi E, et al. Among authors: umbach a.
Front Cell Neurosci. 2019 Jan 10;12:518. doi: 10.3389/fncel.2018.00518. eCollection 2018.
Front Cell Neurosci. 2019.
PMID: 30687010
Free PMC article.
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Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR.
Zamboni V, et al. Among authors: umbach a.
Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877.
Sci Rep. 2016.
PMID: 27713499
Free PMC article.
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