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49 results

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MMP-2 Silencing through siRNA Loaded Positively-Charged Nanoparticles (AcPEI-NPs) Counteracts Chondrocyte De-Differentiation.
Conte R, Finicelli M, Borrone A, Margarucci S, Peluso G, Calarco A, Bosetti M. Conte R, et al. Polymers (Basel). 2023 Feb 25;15(5):1172. doi: 10.3390/polym15051172. Polymers (Basel). 2023. PMID: 36904410 Free PMC article.
The trait of OA is extracellular matrix (ECM) progressive degradation regulated by many factors, in which MMPs play an important role, which indicates them as potential therapeutic targets. Herein, a small interfering RNA (siRNA) delivery system able t …
The trait of OA is extracellular matrix (ECM) progressive degradation regulated by many factors, in which MMPs play an important role, which …
METTL3 regulates WTAP protein homeostasis.
Sorci M, Ianniello Z, Cruciani S, Larivera S, Ginistrelli LC, Capuano E, Marchioni M, Fazi F, Fatica A. Sorci M, et al. Cell Death Dis. 2018 Jul 23;9(8):796. doi: 10.1038/s41419-018-0843-z. Cell Death Dis. 2018. PMID: 30038300 Free PMC article.
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation. In addition, WTAP is also a …
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an …
NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.
Ghosh S, Devereaux MW, Anderson AL, Gehrke S, Reisz JA, D'Alessandro A, Orlicky DJ, Lovell M, El Kasmi KC, Shearn CT, Sokol RJ. Ghosh S, et al. Hepatology. 2021 Dec;74(6):3284-3300. doi: 10.1002/hep.32071. Epub 2021 Aug 27. Hepatology. 2021. PMID: 34310734 Free PMC article.
Treatment of HepG2 cells and primary mouse hepatocytes with an LRH-1 inverse agonist, ML179, significantly reduced mRNA expression of FXR targets ATP binding cassette subfamily C member 2/multidrug resistance associated protein 2 (ABCC2/MRP2), nuclear receptor subfamily 0, groupB …
Treatment of HepG2 cells and primary mouse hepatocytes with an LRH-1 inverse agonist, ML179, significantly reduced mRNA expression of FXR ta …
New agents to reduce cholesterol levels: implications for nephrologists.
Del Vecchio L, Baragetti I, Locatelli F. Del Vecchio L, et al. Nephrol Dial Transplant. 2020 Feb 1;35(2):213-218. doi: 10.1093/ndt/gfz013. Nephrol Dial Transplant. 2020. PMID: 30753594 Review.
This goal is obtained with different therapeutic approaches, spanning from monoclonal antibodies to non sense oligonucleotides and silencing RNA (siRNA). Two human, monoclonal antibodies are approved for clinical use; they are still very expensive. ...Evolocumab and …
This goal is obtained with different therapeutic approaches, spanning from monoclonal antibodies to non sense oligonucleotides and silencing …
Neuroprotective effects of estrogens: the role of cholesterol.
Peri A. Peri A. J Endocrinol Invest. 2016 Jan;39(1):11-8. doi: 10.1007/s40618-015-0332-5. Epub 2015 Jun 18. J Endocrinol Invest. 2016. PMID: 26084445 Review.
Indeed, in cells in which seladin-1 gene expression had been silenced by siRNA the protective effects of estrogens were lost. This finding indicates that seladin-1 is a crucial mediator of the neuroprotective effects of these hormones, at least in our cell model. ...
Indeed, in cells in which seladin-1 gene expression had been silenced by siRNA the protective effects of estrogens were lost. This fi …
Cell migration guided by long-lived spatial memory.
d'Alessandro J, Barbier-Chebbah A, Cellerin V, Benichou O, Mège RM, Voituriez R, Ladoux B. d'Alessandro J, et al. Nat Commun. 2021 Jul 5;12(1):4118. doi: 10.1038/s41467-021-24249-8. Nat Commun. 2021. PMID: 34226542 Free PMC article.
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models.
Assoni G, La Pietra V, Digilio R, Ciani C, Licata NV, Micaelli M, Facen E, Tomaszewska W, Cerofolini L, Pérez-Ràfols A, Varela Rey M, Fragai M, Woodhoo A, Marinelli L, Arosio D, Bonomo I, Provenzani A, Seneci P. Assoni G, et al. Adv Drug Deliv Rev. 2022 Feb;181:114088. doi: 10.1016/j.addr.2021.114088. Epub 2021 Dec 20. Adv Drug Deliv Rev. 2022. PMID: 34942276 Review.
The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously expressed in human tissues, that orchestrates target RNA maturation and processing both in the nucleus and in the cytoplasm. A survey of known modulators of the RNA-HuR interactions is …
The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously expressed in human tissues, that orchestrates target RNA …
Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells.
Pediconi N, Ghirga F, Del Plato C, Peruzzi G, Athanassopoulos CM, Mori M, Crestoni ME, Corinti D, Ugozzoli F, Massera C, Arcovito A, Botta B, Boffi A, Quaglio D, Baiocco P. Pediconi N, et al. Bioconjug Chem. 2021 Jun 16;32(6):1105-1116. doi: 10.1021/acs.bioconjchem.1c00137. Epub 2021 May 12. Bioconjug Chem. 2021. PMID: 33978420 Free PMC article.
Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases through selective gene silencing. ...These systems allowed siRNA delivery into HeLa, HepG2, and MCF-7 cancer cells with improved silen …
Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases t …
Proof-of-Concept Study on the Use of Tangerine-Derived Nanovesicles as siRNA Delivery Vehicles toward Colorectal Cancer Cell Line SW480.
Rabienezhad Ganji N, Urzì O, Tinnirello V, Costanzo E, Polito G, Palumbo Piccionello A, Manno M, Raccosta S, Gallo A, Lo Pinto M, Calligaris M, Scilabra SD, Di Bella MA, Conigliaro A, Fontana S, Raimondo S, Alessandro R. Rabienezhad Ganji N, et al. Int J Mol Sci. 2023 Dec 30;25(1):546. doi: 10.3390/ijms25010546. Int J Mol Sci. 2023. PMID: 38203716 Free PMC article.
We found that the DDHD1-siRNA complex TNVs were able to deliver DDHD1-siRNA to human colorectal cancer cells, inhibiting the target expression by about 60%. This study represents a proof of concept for the use of PDNVs as vehicles of RNA interference (RNAi) t …
We found that the DDHD1-siRNA complex TNVs were able to deliver DDHD1-siRNA to human colorectal cancer cells, inhibiting the t …
49 results