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Page 1
Platinum(IV) complex with adamantylamine as nonleaving amine group: synthesis, characterization, and in vitro antitumor activity against a panel of cisplatin-resistant cancer cell lines.
Zák F, Turánek J, Kroutil A, Sova P, Mistr A, Poulová A, Mikolin P, Zák Z, Kasná A, Záluská D, Neca J, Sindlerová L, Kozubík A. Zák F, et al. Among authors: kroutil a. J Med Chem. 2004 Jan 29;47(3):761-3. doi: 10.1021/jm030858+. J Med Chem. 2004. PMID: 14736257
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro.
Kozubík A, Horváth V, Svihálková-Sindlerová L, Soucek K, Hofmanová J, Sova P, Kroutil A, Zák F, Mistr A, Turánek J. Kozubík A, et al. Among authors: kroutil a. Biochem Pharmacol. 2005 Feb 1;69(3):373-83. doi: 10.1016/j.bcp.2004.09.005. Epub 2004 Dec 23. Biochem Pharmacol. 2005. PMID: 15652229
New platinum(IV) complex with adamantylamine ligand as a promising anti-cancer drug: comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum(IV) complexes.
Turánek J, Kasná A, Záluská D, Neca J, Kvardová V, Knötigová P, Horváth V, SIndlerová L, Kozubík A, Sova P, Kroutil A, Zák F, Mistr A. Turánek J, et al. Among authors: kroutil a. Anticancer Drugs. 2004 Jun;15(5):537-43. doi: 10.1097/01.cad.0000127147.57796.e5. Anticancer Drugs. 2004. PMID: 15166629
A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV).
Sova P, Mistr A, Kroutil A, Semerád M, Chlubnová H, Hrusková V, Chládková J, Chládek J. Sova P, et al. Among authors: kroutil a. Cancer Chemother Pharmacol. 2011 Jun;67(6):1247-56. doi: 10.1007/s00280-010-1411-0. Epub 2010 Aug 10. Cancer Chemother Pharmacol. 2011. PMID: 20697713