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1988 2
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1998 25
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The following term was not found in PubMed: Girona-Ruiz
Page 1
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.
Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, Gao J, Guo W, Lai Y, Ma H, Chen D, Xu Q, Sun Y. Zhu Y, et al. EMBO Mol Med. 2022 Mar 7;14(3):e14455. doi: 10.15252/emmm.202114455. Epub 2021 Dec 22. EMBO Mol Med. 2022. PMID: 34936223 Free PMC article.
We found that the Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) was highly expressed in both psoriatic patients and imiquimod (IMQ)-induced psoriasis-like mice. Also, the SHP2 allosteric inhibitor SHP099 reduced pro-inflammatory cytokine expression …
We found that the Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) was highly expressed in both psoriatic patients and …
Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M. Worley B, et al. Arch Dermatol Res. 2023 Jul;315(5):1099-1108. doi: 10.1007/s00403-022-02490-5. Epub 2022 Dec 1. Arch Dermatol Res. 2023. PMID: 36454335 Review.
The greatest degree of improvement was seen with photodynamic therapy (PDT) used adjunctively with other modalities, but this was not significantly different compared to other treatments. PDT, cryotherapy, imiquimod, ingenol mebutate (IMB), 5-fluorouracil (5-FU), trichloro …
The greatest degree of improvement was seen with photodynamic therapy (PDT) used adjunctively with other modalities, but this was not signif …
IL-23- and Imiquimod-Induced Models of Experimental Psoriasis in Mice.
Singh TP, Zhang HH, Hwang ST, Farber JM. Singh TP, et al. Curr Protoc Immunol. 2019 Jun;125(1):e71. doi: 10.1002/cpim.71. Epub 2019 Jan 7. Curr Protoc Immunol. 2019. PMID: 30615272
Genome-wide association studies have found that polymorphisms in genes for IL-23 and its receptor are important in psoriasis, and blocking IL-23 is an effective therapy in the disease. The use of Aldara() , a cream that contains the TLR7 and TLR8 agonist imiquimod ( …
Genome-wide association studies have found that polymorphisms in genes for IL-23 and its receptor are important in psoriasis, and blocking I …
Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy.
Chen Q, Chen J, Yang Z, Xu J, Xu L, Liang C, Han X, Liu Z. Chen Q, et al. Adv Mater. 2019 Mar;31(10):e1802228. doi: 10.1002/adma.201802228. Epub 2019 Jan 21. Adv Mater. 2019. PMID: 30663118
Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an enzyme that can decompose H(2) O(2) to generate O(2) , inside the inner core, and loading hydrophobic imiquimod (R837), a Toll-like- …
Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, by encapsulating water-soluble catalase (Cat), an …
Pharmacological Agents Used in the Prevention and Treatment of Actinic Keratosis: A Review.
Arcuri D, Ramchatesingh B, Lagacé F, Iannattone L, Netchiporouk E, Lefrançois P, Litvinov IV. Arcuri D, et al. Int J Mol Sci. 2023 Mar 5;24(5):4989. doi: 10.3390/ijms24054989. Int J Mol Sci. 2023. PMID: 36902419 Free PMC article. Review.
Topical 5-FU, including combination formulations with either calcipotriol or salicylic acid, as well as imiquimod, diclofenac and photodynamic light therapy are all accepted treatment strategies employed to target and eliminate AKs. ...Topical diclofenac (3%) appears to be …
Topical 5-FU, including combination formulations with either calcipotriol or salicylic acid, as well as imiquimod, diclofenac and pho …
IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis.
Yu Z, Yu Q, Xu H, Dai X, Yu Y, Cui L, Chen Y, Gu J, Zhang X, Guo C, Shi Y. Yu Z, et al. J Invest Dermatol. 2022 Sep;142(9):2343-2352. doi: 10.1016/j.jid.2022.02.016. Epub 2022 Mar 15. J Invest Dermatol. 2022. PMID: 35304250 Free article.
In this study, we show that the YAP-AREG pathway is activated in human psoriatic skin and is suppressed by IL-17A antagonist secukinumab and that imiquimod and IL-17A administration activates the YAP-AREG axis in mice epidermis. ...
In this study, we show that the YAP-AREG pathway is activated in human psoriatic skin and is suppressed by IL-17A antagonist secukinumab and …
Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication.
Yin Q, Sun L, Cai X, Lou F, Sun Y, Wang B, Jiang B, Bao L, Li X, Song N, Tang S, Bai J, Wang Z, Wu Y, Zhou H, Wang H, Yu B, Li Q, Wang H. Yin Q, et al. J Invest Dermatol. 2022 Aug;142(8):2173-2183.e6. doi: 10.1016/j.jid.2022.01.002. Epub 2022 Jan 12. J Invest Dermatol. 2022. PMID: 35032503 Free article.
Lidocaine treatment markedly reduced patients' clinical scores and improved an imiquimod-induced rat model of psoriasis as competent as systemic delivery of a TNF-alpha antibody. Imiquimod application elicited aberrant cutaneous nerve outgrowth and excessive generat …
Lidocaine treatment markedly reduced patients' clinical scores and improved an imiquimod-induced rat model of psoriasis as competent …
Guidelines of care for the management of actinic keratosis.
Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE. Eisen DB, et al. J Am Acad Dermatol. 2021 Oct;85(4):e209-e233. doi: 10.1016/j.jaad.2021.02.082. Epub 2021 Apr 2. J Am Acad Dermatol. 2021. PMID: 33820677
CONCLUSIONS: Strong recommendations are made for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosurgery. Conditional recommendations are made for the use of photodynamic therapy and diclofenac for the treatment of AK, both individually and …
CONCLUSIONS: Strong recommendations are made for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosur …
Randomized Trial of Four Treatment Approaches for Actinic Keratosis.
Jansen MHE, Kessels JPHM, Nelemans PJ, Kouloubis N, Arits AHMM, van Pelt HPA, Quaedvlieg PJF, Essers BAB, Steijlen PM, Kelleners-Smeets NWJ, Mosterd K. Jansen MHE, et al. N Engl J Med. 2019 Mar 7;380(10):935-946. doi: 10.1056/NEJMoa1811850. N Engl J Med. 2019. PMID: 30855743 Clinical Trial.
Patients were randomly assigned to treatment with 5% fluorouracil cream, 5% imiquimod cream, methyl aminolevulinate photodynamic therapy (MAL-PDT), or 0.015% ingenol mebutate gel. ...As compared with fluorouracil, the hazard ratio for treatment failure was 2.03 (95% CI, 1. …
Patients were randomly assigned to treatment with 5% fluorouracil cream, 5% imiquimod cream, methyl aminolevulinate photodynamic ther …
Management of Condyloma Acuminata in Pregnancy: A Review.
Sugai S, Nishijima K, Enomoto T. Sugai S, et al. Sex Transm Dis. 2021 Jun 1;48(6):403-409. doi: 10.1097/OLQ.0000000000001322. Sex Transm Dis. 2021. PMID: 33093288 Free PMC article.
The treatment methods described in the literature were laser therapy, cryotherapy, imiquimod, photodynamic therapy, trichloroacetic acid, and local hyperthermia. ...Based on our assessment of the literature, we recommend cryotherapy as the first-choice treatment and laser …
The treatment methods described in the literature were laser therapy, cryotherapy, imiquimod, photodynamic therapy, trichloroacetic a …
5,352 results