An efficient scalable synthesis of 2,3-epoxypropyl phenylhydrazones

Vytautas Getautis; Maryte Daskeviciene; Tadas Malinauskas; Albina Stanisauskaite; Jolanta Stumbraite

doi:10.3390/11010064

An efficient scalable synthesis of 2,3-epoxypropyl phenylhydrazones

Molecules. 2006 Jan 31;11(1):64-71. doi: 10.3390/11010064.

Authors

Vytautas Getautis¹, Maryte Daskeviciene, Tadas Malinauskas, Albina Stanisauskaite, Jolanta Stumbraite

Affiliation

¹ Department of Organic Chemistry, Kaunas University of Technology, LT-50270 Kaunas, Lithuania. vytautas.getautis@ktu.lt

Abstract

A series of mono and di-N-2,3-epoxypropyl N-phenylhydrazones have been prepared on a large scale by reaction of the corresponding N-phenylhydrazones of 9-ethyl-3-carbazolecarbaldehyde, 9-ethyl-3,6-carbazoledicarbaldehyde, 4-dimethyl-amino-, 4-diethylamino-, 4-benzylethylamino-, 4-(diphenylamino)-, 4-(4,4-4'-dimethyl-diphenylamino)-, 4-(4-formyldiphenylamino)- and 4-(4-formyl-4'-methyldiphenyl-amino)benzaldehyde with epichlorohydrin in the presence of KOH and anhydrous Na(2)SO(4).

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Efficiency
Epichlorohydrin / chemistry
Heterocyclic Compounds / chemical synthesis
Hydrazones / chemical synthesis*
Models, Biological

Substances

Heterocyclic Compounds
Hydrazones
phenylhydrazone
Epichlorohydrin