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A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Alegre-Martí A, Jiménez-Panizo A, Martínez-Tébar A, Poulard C, Peralta-Moreno MN, Abella M, Antón R, Chiñas M, Eckhard U, Piulats JM, Rojas AM, Fernández-Recio J, Rubio-Martínez J, Le Romancer M, Aytes Á, Fuentes-Prior P, Estébanez-Perpiñá E. Alegre-Martí A, et al. Among authors: jimenez panizo a. Sci Adv. 2023 Mar 17;9(11):eade2175. doi: 10.1126/sciadv.ade2175. Epub 2023 Mar 15. Sci Adv. 2023. PMID: 36921044 Free PMC article.
The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
Jiménez-Panizo A, Alegre-Martí A, Tettey TT, Fettweis G, Abella M, Antón R, Johnson TA, Kim S, Schiltz RL, Núñez-Barrios I, Font-Díaz J, Caelles C, Valledor AF, Pérez P, Rojas AM, Fernández-Recio J, Presman DM, Hager GL, Fuentes-Prior P, Estébanez-Perpiñá E. Jiménez-Panizo A, et al. Nucleic Acids Res. 2022 Dec 9;50(22):13063-13082. doi: 10.1093/nar/gkac1119. Nucleic Acids Res. 2022. PMID: 36464162 Free PMC article.
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.
Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jiménez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Estébanez-Perpiñá E, Venken K, Moore DD, Young DW, Maletic-Savatic M. Kandel P, et al. Among authors: jimenez panizo a. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2023784119. doi: 10.1073/pnas.2023784119. Epub 2022 Mar 25. Proc Natl Acad Sci U S A. 2022. PMID: 35333654 Free PMC article.