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The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice.
Nat Commun. 2020 Nov 11;11(1):5701. doi: 10.1038/s41467-020-19532-z.
Nat Commun. 2020.
PMID: 33177522
Free PMC article.
TAGing for destruction.
Yesbolatova A, Kanemaki MT.
Yesbolatova A, et al.
Nat Chem Biol. 2018 May;14(5):414-415. doi: 10.1038/s41589-018-0024-5.
Nat Chem Biol. 2018.
PMID: 29581583
No abstract available.
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Ligand-induced genetic degradation as a tool for target validation.
Yesbolatova A, Tominari Y, Kanemaki MT.
Yesbolatova A, et al.
Drug Discov Today Technol. 2019 Apr;31:91-98. doi: 10.1016/j.ddtec.2018.11.001. Epub 2018 Nov 24.
Drug Discov Today Technol. 2019.
PMID: 31200864
Review.
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Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector.
Yesbolatova A, Saito Y, Kanemaki MT.
Yesbolatova A, et al.
Pharmaceuticals (Basel). 2020 May 23;13(5):103. doi: 10.3390/ph13050103.
Pharmaceuticals (Basel). 2020.
PMID: 32456235
Free PMC article.
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Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole.
Yesbolatova A, Natsume T, Hayashi KI, Kanemaki MT.
Yesbolatova A, et al.
Methods. 2019 Jul 15;164-165:73-80. doi: 10.1016/j.ymeth.2019.04.010. Epub 2019 Apr 24.
Methods. 2019.
PMID: 31026591
Free article.
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