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Showing results for amine n. O'Sullivan
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Solid-phase biotinylation of antibodies.
Strachan E, Mallia AK, Cox JM, Antharavally B, Desai S, Sykaluk L, O'Sullivan V, Bell PA. Strachan E, et al. J Mol Recognit. 2004 May-Jun;17(3):268-76. doi: 10.1002/jmr.669. J Mol Recognit. 2004. PMID: 15137036
Excess reagents are easily washed away following reaction, and biotinylated IgG molecule is recovered under mild elution conditions. Successful solid phase labeling of antibodies through both amine and sulfhydryl groups is reported, in both column and mini-spin column form …
Excess reagents are easily washed away following reaction, and biotinylated IgG molecule is recovered under mild elution conditions. Success …
Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase.
Shanahan P, O'Sullivan J, Tipton KF, Kinsella GK, Ryan BJ, Henehan GTM. Shanahan P, et al. J Food Biochem. 2019 Feb;43(2):e12697. doi: 10.1111/jfbc.12697. Epub 2018 Oct 15. J Food Biochem. 2019. PMID: 31353656
Methylxanthines are among the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years. Primary Amine Oxidase (PrAO) has been recognized as a therapeutic target for the amelioration of inflammatory, vascular, and neurod …
Methylxanthines are among the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years …
Mixed hydroxypyridinonate ligands as iron chelators.
Cohen SM, O'Sullivan B, Raymond KN. Cohen SM, et al. Inorg Chem. 2000 Sep 18;39(19):4339-46. doi: 10.1021/ic000239g. Inorg Chem. 2000. PMID: 11196930
New ligands based on hydroxypyridinonate (HOPO) and other bidentate ligands are explored as iron(III) sequestering agents. These are based on the N,N',N"-tris[(3-hydroxy-1-methyl- 2-oxo-1,2-didehydropyrid-4-yl)-carboxamidoethyl]amine (TREN-Me-3,2-HOPO) …
New ligands based on hydroxypyridinonate (HOPO) and other bidentate ligands are explored as iron(III) sequestering agents. These are based o …
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA, Kelly TA, Jenuwein T. Kubicek S, et al. Mol Cell. 2007 Feb 9;25(3):473-81. doi: 10.1016/j.molcel.2007.01.017. Mol Cell. 2007. PMID: 17289593 Free article.
From a chemical library comprising 125,000 preselected compounds, seven hits were identified. Of those, one inhibitor, BIX-01294 (diazepin-quinazolin-amine derivative), does not compete with the cofactor S-adenosyl-methionine, and selectively impairs the G9a HMTase and the …
From a chemical library comprising 125,000 preselected compounds, seven hits were identified. Of those, one inhibitor, BIX-01294 (diazepin-q …
Hexadentate hydroxypyridonate iron chelators based on TREN-Me-3,2-HOPO: variation of cap size.
Xu J, O'Sullivan B, Raymond KN. Xu J, et al. Inorg Chem. 2002 Dec 16;41(25):6731-42. doi: 10.1021/ic025610+. Inorg Chem. 2002. PMID: 12470069
Single crystal X-ray structures are reported for the ferric complexes of all four tripodal ligands: FeTREN-Me-3,2-HOPO.0.375C(4)H(10)O.0.5CH(2)Cl(2) [P2(1)/n (No. 14), Z = 8, a = 20.478(3) A, b = 12.353(2) A, c = 27.360(3) A; beta = 91.60(1) degrees ]; FeTR322-Me-3,2-HOPO. …
Single crystal X-ray structures are reported for the ferric complexes of all four tripodal ligands: FeTREN-Me-3,2-HOPO.0.375C(4)H(10)O.0.5CH …
Efficient, stereoselective synthesis of oxazolo[3,2-a]pyrazin-5-ones: novel bicyclic lactam scaffolds from the bicyclocondensation of 3-aza-1,5-ketoacids and amino alcohols.
Bencsik JR, Kercher T, O'Sullivan M, Josey JA. Bencsik JR, et al. Org Lett. 2003 Jul 24;5(15):2727-30. doi: 10.1021/ol030065h. Org Lett. 2003. PMID: 12868900
Mild oxidation of serinol-derived scaffolds provided access to a new class of constrained dipeptide surrogates. Deprotection of the endocyclic amine contained within these scaffolds allows for further diversification via N-functionalization....
Mild oxidation of serinol-derived scaffolds provided access to a new class of constrained dipeptide surrogates. Deprotection of the endocycl …
The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses.
O'Sullivan J, O'Sullivan M, Tipton KF, Unzeta M, Del Mar Hernandez M, Davey GP. O'Sullivan J, et al. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):367-71. doi: 10.1016/s1570-9639(03)00096-7. Biochim Biophys Acta. 2003. PMID: 12686159
Semicarbazide-sensitive amine oxidase (EC 1.4.3.6; amine:oxygen oxidoreductase (deaminating) (copper-containing); SSAO) is a multifunctional protein. ...The relationships, if any, between this adhesion function and the enzymatic functions (amine-substrate spe …
Semicarbazide-sensitive amine oxidase (EC 1.4.3.6; amine:oxygen oxidoreductase (deaminating) (copper-containing); SSAO) is a m …
Molecular features necessary for the uptake of diamines and related compounds by the polyamine receptor of rat lung slices.
O'Sullivan MC, Golding BT, Smith LL, Wyatt I. O'Sullivan MC, et al. Biochem Pharmacol. 1991 Jun 15;41(12):1839-48. doi: 10.1016/0006-2952(91)90122-l. Biochem Pharmacol. 1991. PMID: 1645551
Apparent Ki values of the putrescine derivatives increase, and thus the inhibitory effects decrease, with increasing N-methylation. Comparison of N-methyl-1,4-diaminobutane (Ki = 8 microM) with N,N'-bis-methyl-1,4-diaminobutane (Ki = 25.5 microM) shows …
Apparent Ki values of the putrescine derivatives increase, and thus the inhibitory effects decrease, with increasing N-methylation. C …
Synthesis of a ligand based upon a new entry into the 3-hydroxy-N-alkyl-2(1H)-pyridinone ring system and thermodynamic evaluation of its gadolinium complex.
Johnson AR, O'Sullivan B, Raymond KN. Johnson AR, et al. Inorg Chem. 2000 Jun 12;39(12):2652-60. doi: 10.1021/ic991471t. Inorg Chem. 2000. PMID: 11197022
The synthesis of a new, more water soluble derivative of TREN-Me-3,2-HOPO (tris[(3-hydroxy-1-methyl-2-oxo-1,2- didehydropyridine-4-carboxamido)ethyl]amine) is presented. The synthesis starts with the condensation reaction of (N-methoxyethylamino)acetonitrile hydroch …
The synthesis of a new, more water soluble derivative of TREN-Me-3,2-HOPO (tris[(3-hydroxy-1-methyl-2-oxo-1,2- didehydropyridine-4-carboxami …