Abstract
The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptor binding affinity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic Antagonists / chemical synthesis*
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Adrenergic Antagonists / chemistry
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Adrenergic Antagonists / pharmacology*
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Adrenergic alpha-1 Receptor Antagonists
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Adrenergic alpha-2 Receptor Antagonists
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Adrenergic beta-1 Receptor Antagonists
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Animals
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Anti-Arrhythmia Agents / chemical synthesis
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Anti-Arrhythmia Agents / chemistry
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Anti-Arrhythmia Agents / therapeutic use
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / drug therapy
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Blood Pressure / drug effects
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Electrocardiography
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Epinephrine / toxicity
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Ileum / drug effects
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Propanolamines / chemical synthesis*
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Propanolamines / chemistry
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Propanolamines / therapeutic use*
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Rabbits
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Rats
Substances
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Adrenergic Antagonists
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Adrenergic alpha-1 Receptor Antagonists
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Adrenergic alpha-2 Receptor Antagonists
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Adrenergic beta-1 Receptor Antagonists
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Anti-Arrhythmia Agents
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Propanolamines
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Epinephrine