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Page 1
Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors.
J Med Chem. 2020 Jul 23;63(14):7695-7720. doi: 10.1021/acs.jmedchem.0c00520. Epub 2020 Jul 7.
J Med Chem. 2020.
PMID: 32633513
Free PMC article.
Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA.
Qiu Y, Chu AJ, Tsang TF, Zheng Y, Lam NM, Li KSL, Ip M, Yang X, Ma C.
Qiu Y, et al. Among authors: chu aj.
Bioorg Chem. 2022 Jul;124:105863. doi: 10.1016/j.bioorg.2022.105863. Epub 2022 May 12.
Bioorg Chem. 2022.
PMID: 35580381
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Multi-methodological approach for the Quality assessment of Senecionis scandentis Herba (Qianliguang) in the herbal market.
Ngai HL, Yang X, Chu AJ, Harper R, Jacobsen ABJE, Lau DT, Yu HY, Lee HK, Shaw PC.
Ngai HL, et al. Among authors: chu aj.
PLoS One. 2022 Apr 14;17(4):e0267143. doi: 10.1371/journal.pone.0267143. eCollection 2022.
PLoS One. 2022.
PMID: 35421189
Free PMC article.
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Benzyl and benzoyl benzoic acid inhibitors of bacterial RNA polymerase-sigma factor interaction.
Ye J, Chu AJ, Lin L, Chan ST, Harper R, Xiao M, Artsimovitch I, Zuo Z, Ma C, Yang X.
Ye J, et al. Among authors: chu aj.
Eur J Med Chem. 2020 Dec 15;208:112671. doi: 10.1016/j.ejmech.2020.112671. Epub 2020 Aug 18.
Eur J Med Chem. 2020.
PMID: 32920341
Free PMC article.
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First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae.
Ye J, Chu AJ, Lin L, Yang X, Ma C.
Ye J, et al. Among authors: chu aj.
Molecules. 2019 Aug 9;24(16):2902. doi: 10.3390/molecules24162902.
Molecules. 2019.
PMID: 31405060
Free PMC article.
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Nusbiarylins Inhibit Transcription and Target Virulence Factors in Bacterial Pathogen Staphylococcus aureus.
Chu AJ, Qiu Y, Harper R, Lin L, Ma C, Yang X.
Chu AJ, et al.
Int J Mol Sci. 2020 Aug 11;21(16):5772. doi: 10.3390/ijms21165772.
Int J Mol Sci. 2020.
PMID: 32796751
Free PMC article.
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Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria.
Ye J, Kan CH, Zheng Y, Tsang TF, Chu AJ, Chan KH, Yang X, Ma C.
Ye J, et al. Among authors: chu aj.
Bioorg Chem. 2024 Feb;143:106983. doi: 10.1016/j.bioorg.2023.106983. Epub 2023 Nov 23.
Bioorg Chem. 2024.
PMID: 38016396
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