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Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.
Bollenbach M, Salvat E, Daubeuf F, Wagner P, Yalcin I, Humo M, Letellier B, Becker LJ, Bihel F, Bourguignon JJ, Villa P, Obrecht A, Frossard N, Barrot M, Schmitt M. Bollenbach M, et al. Among authors: obrecht a. Eur J Med Chem. 2018 Mar 10;147:163-182. doi: 10.1016/j.ejmech.2018.01.049. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29432948 Review.
Engineering Novel 3D Models to Recreate High-Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment.
Pierrevelcin M, Flacher V, Mueller CG, Vauchelles R, Guerin E, Lhermitte B, Pencreach E, Reisch A, Muller Q, Doumard L, Boufenghour W, Klymchenko AS, Foppolo S, Nazon C, Weingertner N, Martin S, Briandet C, Laithier V, Di Marco A, Bund L, Obrecht A, Villa P, Dontenwill M, Entz-Werlé N. Pierrevelcin M, et al. Among authors: obrecht a. Adv Healthc Mater. 2022 Oct;11(19):e2200195. doi: 10.1002/adhm.202200195. Epub 2022 Sep 4. Adv Healthc Mater. 2022. PMID: 36057996
Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
Nemska S, Daubeuf F, Obrecht A, Israel-Biet D, Stern M, Kessler R, Roux A, Tavakoli R, Villa P, Tissot A, Danger R, Reber L, Durand E, Foureau A, Brouard S, Magnan A, Frossard N; COLT consortium. Nemska S, et al. Among authors: obrecht a. Transplantation. 2021 Jun 1;105(6):1212-1224. doi: 10.1097/TP.0000000000003606. Transplantation. 2021. PMID: 33560725
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.
Calas AG, Hanak AS, Jaffré N, Nervo A, Dias J, Rousseau C, Courageux C, Brazzolotto X, Villa P, Obrecht A, Goossens JF, Landry C, Hachani J, Gosselet F, Dehouck MP, Yerri J, Kliachyna M, Baati R, Nachon F. Calas AG, et al. Among authors: obrecht a. Biomolecules. 2020 Jun 4;10(6):858. doi: 10.3390/biom10060858. Biomolecules. 2020. PMID: 32512884 Free PMC article.
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
Bollenbach M, Nemska S, Wagner P, Camelin G, Daubeuf F, Obrecht A, Villa P, Rognan D, Bihel F, Bourguignon JJ, Schmitt M, Frossard N. Bollenbach M, et al. Among authors: obrecht a. Molecules. 2021 Jan 13;26(2):391. doi: 10.3390/molecules26020391. Molecules. 2021. PMID: 33450992 Free PMC article.
Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity.
Blandin AF, Durand A, Litzler M, Tripp A, Guérin É, Ruhland E, Obrecht A, Keime C, Fuchs Q, Reita D, Lhermitte B, Coca A, Jones C, Rebel IL, Villa P, Namer IJ, Dontenwill M, Guenot D, Entz-Werle N. Blandin AF, et al. Among authors: obrecht a. Cancers (Basel). 2019 Nov 26;11(12):1875. doi: 10.3390/cancers11121875. Cancers (Basel). 2019. PMID: 31779235 Free PMC article.
Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae).
Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron-Sénécheau C, Villa P, Obrecht A, Eparvier V, Deharo E, Stien D. Houël E, et al. Among authors: obrecht a. J Ethnopharmacol. 2015 May 26;166:279-85. doi: 10.1016/j.jep.2015.03.015. Epub 2015 Mar 16. J Ethnopharmacol. 2015. PMID: 25792015
Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians.
Houël E, Nardella F, Jullian V, Valentin A, Vonthron-Sénécheau C, Villa P, Obrecht A, Kaiser M, Bourreau E, Odonne G, Fleury M, Bourdy G, Eparvier V, Deharo E, Stien D. Houël E, et al. Among authors: obrecht a. J Ethnopharmacol. 2016 Jul 1;187:241-8. doi: 10.1016/j.jep.2016.04.053. Epub 2016 Apr 28. J Ethnopharmacol. 2016. PMID: 27132714