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T cell activation is insufficient to drive SIV disease progression.
Apetrei C, Gaufin T, Brocca-Cofano E, Sivanandham R, Sette P, He T, Sivanandham S, Martinez Sosa N, Martin KJ, Raehtz KD, Kleinman AJ, Valentine A, Krampe N, Gautam R, Lackner AA, Landay AL, Ribeiro RM, Pandrea I. Apetrei C, et al. Among authors: kleinman aj. JCI Insight. 2023 Jul 24;8(14):e161111. doi: 10.1172/jci.insight.161111. JCI Insight. 2023. PMID: 37485874 Free PMC article.
Regulatory T Cells As Potential Targets for HIV Cure Research.
Kleinman AJ, Sivanandham R, Pandrea I, Chougnet CA, Apetrei C. Kleinman AJ, et al. Front Immunol. 2018 Apr 13;9:734. doi: 10.3389/fimmu.2018.00734. eCollection 2018. Front Immunol. 2018. PMID: 29706961 Free PMC article. Review.
Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques.
Kleinman AJ, Xu C, Cottrell ML, Sivanandham R, Brocca-Cofano E, Dunsmore T, Kashuba A, Pandrea I, Apetrei C. Kleinman AJ, et al. Front Immunol. 2020 Dec 11;11:579158. doi: 10.3389/fimmu.2020.579158. eCollection 2020. Front Immunol. 2020. PMID: 33362765 Free PMC article.
Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations.
Kleinman AJ, Sivanandham S, Sette P, Sivanandham R, Policicchio BB, Xu C, Penn E, Brocca-Cofano E, Le Hingrat Q, Ma D, Pandrea I, Apetrei C. Kleinman AJ, et al. J Virol. 2022 Jun 22;96(12):e0044522. doi: 10.1128/jvi.00445-22. Epub 2022 May 31. J Virol. 2022. PMID: 35638831 Free PMC article.
Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus.
Sivanandham R, Kleinman AJ, Sette P, Brocca-Cofano E, Kilapandal Venkatraman SM, Policicchio BB, He T, Xu C, Swarthout J, Wang Z, Pandrea I, Apetrei C. Sivanandham R, et al. Among authors: kleinman aj. J Virol. 2020 Sep 15;94(19):e00533-20. doi: 10.1128/JVI.00533-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32669326 Free PMC article.