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Page 1
Inhalation by design.
Jones LH, Hughes AD. Jones LH, et al. Among authors: hughes ad. Future Med Chem. 2011 Oct;3(13):1563-5. doi: 10.4155/fmc.11.132. Future Med Chem. 2011. PMID: 21942245 Free article. No abstract available.
Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition.
Maher JM, Zhang R, Palanisamy G, Perkins K, Liu L, Brassil P, McNamara A, Lo A, Hughes AD, Kanodia J, Kulyk S, Nikula KJ, Dengler HS, Scandurra A, Lua I, Harstad E. Maher JM, et al. Among authors: hughes ad. Toxicol Appl Pharmacol. 2022 Mar 1;438:115905. doi: 10.1016/j.taap.2022.115905. Epub 2022 Feb 3. Toxicol Appl Pharmacol. 2022. PMID: 35122773 Free article.
Biogas from Macroalgae: is it time to revisit the idea?
Hughes AD, Kelly MS, Black KD, Stanley MS. Hughes AD, et al. Biotechnol Biofuels. 2012 Nov 27;5(1):86. doi: 10.1186/1754-6834-5-86. Biotechnol Biofuels. 2012. PMID: 23186536 Free PMC article.
Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and β₂ agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Hughes AD, Chen Y, Hegde SS, Jasper JR, Jaw-Tsai S, Lee TW, McNamara A, Pulido-Rios MT, Steinfeld T, Mammen M. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22. doi: 10.1021/jm501915g. Epub 2015 Feb 9. J Med Chem. 2015. PMID: 25629394
19 results