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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1968 1
1969 4
1970 4
1971 4
1972 2
1973 5
1974 9
1975 38
1976 50
1977 61
1978 60
1979 67
1980 113
1981 110
1982 156
1983 186
1984 241
1985 231
1986 239
1987 285
1988 291
1989 370
1990 385
1991 400
1992 444
1993 486
1994 527
1995 572
1996 651
1997 729
1998 739
1999 755
2000 822
2001 822
2002 850
2003 925
2004 945
2005 991
2006 1065
2007 1087
2008 1155
2009 993
2010 1084
2011 1081
2012 1119
2013 1166
2014 1355
2015 1368
2016 1458
2017 1472
2018 1445
2019 1359
2020 1416
2021 1483
2022 1362
2023 1300
2024 586

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The following term was not found in PubMed: xotyeni
Page 1
Showing results for agonist e xotyeni
Your search for Abonisiwe Xotyeni retrieved no results
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
Bossart M, Wagner M, Elvert R, Evers A, Hübschle T, Kloeckener T, Lorenz K, Moessinger C, Eriksson O, Velikyan I, Pierrou S, Johansson L, Dietert G, Dietz-Baum Y, Kissner T, Nowotny I, Einig C, Jan C, Rharbaoui F, Gassenhuber J, Prochnow HP, Agueusop I, Porksen N, Smith WB, Nitsche A, Konkar A. Bossart M, et al. Cell Metab. 2022 Jan 4;34(1):59-74.e10. doi: 10.1016/j.cmet.2021.12.005. Epub 2021 Dec 20. Cell Metab. 2022. PMID: 34932984 Free article.
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have demonstrated reduction in body weight and improved glucose control in rodent models. We developed SAR441255, a sy …
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) …
Small-molecule AT2 receptor agonists.
Hallberg M, Sumners C, Steckelings UM, Hallberg A. Hallberg M, et al. Med Res Rev. 2018 Mar;38(2):602-624. doi: 10.1002/med.21449. Epub 2017 Jun 13. Med Res Rev. 2018. PMID: 28609561 Review.
The sulfonylcarbamate derivative 8, encompassing a phenylthiofen scaffold is the drug-like agonist with the highest affinity for the AT2R reported to date (K(i) = 0.4 nM). ...Furthermore, the consequences of migration of the methylene imidazole group and presumed structura …
The sulfonylcarbamate derivative 8, encompassing a phenylthiofen scaffold is the drug-like agonist with the highest affinity for the …
Alpha-1 Receptor Agonists.
Dean II JS, Reddivari AKR. Dean II JS, et al. 2023 Jun 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jun 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31869162 Free Books & Documents.
Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypoperfusion, septic shock, cardiopulmonary arrest, heart failure decompensation, as well as other lower acuity conditions. This activity revie …
Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypo …
Design of Oxytocin Analogs.
Wiśniewski K. Wiśniewski K. Methods Mol Biol. 2019;2001:235-271. doi: 10.1007/978-1-4939-9504-2_11. Methods Mol Biol. 2019. PMID: 31134574 Review.
Oxytocin is one of the most extensively studied cyclic peptides and since the elucidation of its structure in 1953 thousands of peptidic OT analogs with antagonistic and agonistic properties have been synthesized and biologically evaluated. ...Many other OT analogs with im …
Oxytocin is one of the most extensively studied cyclic peptides and since the elucidation of its structure in 1953 thousands of peptidic OT …
Mechanisms underlying agonist efficacy.
Strange PG. Strange PG. Biochem Soc Trans. 2007 Aug;35(Pt 4):733-6. doi: 10.1042/BST0350733. Biochem Soc Trans. 2007. PMID: 17635136 Review.
Agonist efficacy is a measure of how well an agonist can stimulate a response system linked to a receptor. Efficacy can be assessed in functional assays and various parameters (E(max), K(A)/EC(50), E(max).K(A)/EC(50)) determined. The E(max).K(A) …
Agonist efficacy is a measure of how well an agonist can stimulate a response system linked to a receptor. Efficacy can be ass …
Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors.
Strange PG. Strange PG. Br J Pharmacol. 2008 Apr;153(7):1353-63. doi: 10.1038/sj.bjp.0707672. Epub 2008 Jan 28. Br J Pharmacol. 2008. PMID: 18223670 Free PMC article. Review.
Also in pharmacological functional studies, good estimates of agonist dissociation constants are possible. Efficacy can be quantitated in several ways based on functional data (maximal effect of the agonist (E(max)), ratio of agonist dissociation const …
Also in pharmacological functional studies, good estimates of agonist dissociation constants are possible. Efficacy can be quantitate …
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T. Iio K, et al. J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12. J Med Chem. 2023. PMID: 37043436
However, an OX(1)R-selective agonist has not yet been reported, despite the importance of the biological function of OX(1)R. Herein, we report the discovery of a potent OX(1)R-selective agonist, (R,E)-3-(4-methoxy-3-(N-(8-(2-(3-methoxyphenyl)-N-methylacetamid …
However, an OX(1)R-selective agonist has not yet been reported, despite the importance of the biological function of OX(1)R. Herein, …
Agonist-selective mechanisms of GPCR desensitization.
Kelly E, Bailey CP, Henderson G. Kelly E, et al. Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S379-88. doi: 10.1038/sj.bjp.0707604. Epub 2007 Dec 3. Br J Pharmacol. 2008. PMID: 18059321 Free PMC article. Review.
With regard to desensitization, distinct agonist-activated conformations of a GPCR could undergo different molecular mechanisms of desensitization. ...There is evidence that other GPCRs also undergo agonist-selective desensitization, but the full therapeutic consequ …
With regard to desensitization, distinct agonist-activated conformations of a GPCR could undergo different molecular mechanisms of de …
EP4 agonist.
Gandhi S, Jain S, Valiathan A. Gandhi S, et al. Am J Orthod Dentofacial Orthop. 2008 Feb;133(2):184; author reply 184-5. doi: 10.1016/j.ajodo.2007.12.013. Am J Orthod Dentofacial Orthop. 2008. PMID: 18249273 No abstract available.
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Kenakin T, Strachan RT. Kenakin T, et al. Trends Pharmacol Sci. 2018 Aug;39(8):748-765. doi: 10.1016/j.tips.2018.05.001. Epub 2018 Jun 7. Trends Pharmacol Sci. 2018. PMID: 29885909 Review.
Here we introduce a unique class of negative allosteric modulator (NAM) - the positive allosteric modulator (PAM)-antagonist - that increases the affinity of the receptor for the agonist but concomitantly decreases agonist efficacy when cobound. Notably, the recipro …
Here we introduce a unique class of negative allosteric modulator (NAM) - the positive allosteric modulator (PAM)-antagonist - that increase …
33,349 results
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