Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Tonglin Pan; Yuan Shi; Guo Yu; Abdureshid Mamtimin; Wei Zhu

doi:10.3390/biom13111652

Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Biomolecules. 2023 Nov 14;13(11):1652. doi: 10.3390/biom13111652.

Authors

Tonglin Pan^{1

2}, Yuan Shi^{1

2}, Guo Yu^{1

2}, Abdureshid Mamtimin^{1

2}, Wei Zhu^{1

2}

Affiliations

¹ Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200090, China.
² Neurosurgical Institute, Fudan University, Shanghai 200032, China.

Abstract

Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.

Keywords: intracranial aneurysm; lipid metabolism disorder; statin; subarachnoid hemorrhage.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Cells
Humans
Intracranial Aneurysm* / etiology
Lipid Metabolism
Lipid Metabolism Disorders*
Lipids

Substances

Lipids

Grants and funding

This study was supported by the National Natural Science Foundation of China (No. 82171311 to W.Z., No. 82271339 to P.L.), Shanghai Excellent Academic Leader Program (No. 21XD1400600 to W.Z.), Clinical Research Plan of SHDC (No. SHDC2020CR2034B to W.Z., No. SHDC2020CR4033 to K.Q.), Shanghai Science and Technology Commission Project (No. 23ZR1408700 to K.Q.), Shanghai Sailing Program (23Y1404500 to Y.S.), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and Zhang Jiang Laboratory, and CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-5-008).