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Page 1
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper.
Abdul-Aziz MH, Alffenaar JC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, Neely MN, Paiva JA, Pea F, Sjovall F, Timsit JF, Udy AA, Wicha SG, Zeitlinger M, De Waele JJ, Roberts JA; Infection Section of European Society of Intensive Care Medicine (ESICM); Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID); Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT); Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC). Abdul-Aziz MH, et al. Intensive Care Med. 2020 Jun;46(6):1127-1153. doi: 10.1007/s00134-020-06050-1. Epub 2020 May 7. Intensive Care Med. 2020. PMID: 32383061 Free PMC article. Review.
This Position Paper also provides a practical guide on how TDM can be applied in routine clinical practice to improve therapeutic outcomes in critically ill adult patients. METHODS: Literature review and analysis were performed by Panel Members nominated by the endorsing o …
This Position Paper also provides a practical guide on how TDM can be applied in routine clinical practice to improve therapeutic outcomes i …
Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation.
Shekar K, Abdul-Aziz MH, Cheng V, Burrows F, Buscher H, Cho YJ, Corley A, Diehl A, Gilder E, Jakob SM, Kim HS, Levkovich BJ, Lim SY, McGuinness S, Parke R, Pellegrino V, Que YA, Reynolds C, Rudham S, Wallis SC, Welch SA, Zacharias D, Fraser JF, Roberts JA. Shekar K, et al. Am J Respir Crit Care Med. 2023 Mar 15;207(6):704-720. doi: 10.1164/rccm.202207-1393OC. Am J Respir Crit Care Med. 2023. PMID: 36215036 Clinical Trial.
Rationale: Data suggest that altered antimicrobial concentrations are likely during extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis was to describe the pharmacokinetics (PKs) of antimicrobials in critically ill adult patients receiv …
Rationale: Data suggest that altered antimicrobial concentrations are likely during extracorporeal membrane oxygenation (ECMO). Objectives: …
Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials.
Roberts JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, Cotta MO, Myburgh J, Bellomo R, Lipman J. Roberts JA, et al. Am J Respir Crit Care Med. 2016 Sep 15;194(6):681-91. doi: 10.1164/rccm.201601-0024OC. Am J Respir Crit Care Med. 2016. PMID: 26974879
RATIONALE: Optimization of beta-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe sepsis. OBJECTIVES: In this individual patient data meta-analysis of critically ill patients with severe sepsis, we aimed to compare …
RATIONALE: Optimization of beta-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe …
Use of Telemedicine for Postdischarge Assessment of the Surgical Wound: International Cohort Study, and Systematic Review With Meta-analysis.
NIHR Global Health Research Unit on Global Surgery, GlobalSurg Collaborative. NIHR Global Health Research Unit on Global Surgery, GlobalSurg Collaborative. Ann Surg. 2023 Jun 1;277(6):e1331-e1347. doi: 10.1097/SLA.0000000000005506. Epub 2022 Jun 27. Ann Surg. 2023. PMID: 36626409 Free PMC article.
The second part combined this data with the results of a systematic review to perform a meta-analysis of all available data conducted in accordance with PRIMSA guidelines (PROSPERO:192596). ...In 9 eligible nonrandomized studies identified, a pooled mean of 64% of patients …
The second part combined this data with the results of a systematic review to perform a meta-analysis of all available data conducted …
Population Pharmacokinetics and Dosing Simulations of Ampicillin and Sulbactam in Hospitalised Adult Patients.
Setiawan E, Cotta MO, Abdul-Aziz MH, Widjanarko D, Sosilya H, Lukas DL, Wallis SC, Parker S, Roberts JA. Setiawan E, et al. Clin Pharmacokinet. 2023 Apr;62(4):573-586. doi: 10.1007/s40262-023-01219-5. Epub 2023 Feb 28. Clin Pharmacokinet. 2023. PMID: 36853585 Free PMC article.
Total ampicillin and sulbactam concentrations were measured by chromatographic assay and pharmacokinetic parameters were estimated using Pmetrics(). ...
Total ampicillin and sulbactam concentrations were measured by chromatographic assay and pharmacokinetic parameters were estimated us …
Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety.
Ruiz-Sancho A, Núñez-Núñez M, Castelo-Corral L, Martínez-Marcos FJ, Lois-Martínez N, Abdul-Aziz MH, Vinuesa-García D. Ruiz-Sancho A, et al. Front Pharmacol. 2023 Jun 28;14:1185602. doi: 10.3389/fphar.2023.1185602. eCollection 2023. Front Pharmacol. 2023. PMID: 37448966 Free PMC article.
Medical records of all adult patients with documented vascular or orthopedic chronic prosthetic infections, who received dalbavancin as SAT between 2016 and 2018 from four Spanish hospitals were reviewed for inclusion. Descriptive analysis of demographic characteristics, C …
Medical records of all adult patients with documented vascular or orthopedic chronic prosthetic infections, who received dalbavancin as SAT …
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.
GlobalSurg Collaborative. GlobalSurg Collaborative. BJS Open. 2019 Feb 28;3(3):403-414. doi: 10.1002/bjs5.50138. eCollection 2019 Jun. BJS Open. 2019. PMID: 31891112 Free PMC article.
This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. METHODS: This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult pat …
This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. METHODS: This study comprised an …
56 results