Abstract
A new synthesis of glycosylthioureas containing a quinazolinone nucleus is described utilizing per-O-acetylglycopyranosylisothiocyanates and several aminoquinazolinones as starting compounds. Structural proofs of these compounds are provided from elemental analyses, IR, 1H and 13C NMR spectra and mass spectra. The biological activity of these compounds has been studied.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Carbon Isotopes / chemistry
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Carbon Isotopes / metabolism
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HIV / drug effects
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Magnetic Resonance Spectroscopy
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Oncogenic Viruses / drug effects
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Quinazolines / metabolism*
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Spectrophotometry, Infrared
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Thiourea / analogs & derivatives
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Thiourea / chemical synthesis*
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Thiourea / pharmacology
Substances
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Antiviral Agents
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Carbon Isotopes
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Quinazolines
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Thiourea