The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies to safeguard nuclear facilities and to verify the States' compliance with the agreements. Recent advancement in these detectors has made it possible to leverage them to reduce the likelihood of an undetected diversion of irradiated nuclear material. Here we show the sensitivity of antineutrino monitors to fuel divergence from two reactor types: a traditional light-water reactor and an advanced sodium-cooled reactor design, a likely candidate for future deployment. The analysis demonstrates that a variety of potential diversion scenarios can be detected by such a system. We outline recent developments in monitoring capabilities and discuss their potential security implications to the international community.