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Page 1
Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.
Widen JC, Kempema AM, Villalta PW, Harki DA. Widen JC, et al. Among authors: kempema am. ACS Chem Biol. 2017 Jan 20;12(1):102-113. doi: 10.1021/acschembio.6b00751. Epub 2016 Nov 28. ACS Chem Biol. 2017. PMID: 28103680 Free PMC article.
Parthenolide prodrug LC-1 slows growth of intracranial glioma.
Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Hexum JK, et al. Among authors: kempema am. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2493-5. doi: 10.1016/j.bmcl.2015.04.058. Epub 2015 Apr 25. Bioorg Med Chem Lett. 2015. PMID: 25978958
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Kempema AM, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4737-4745. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30. Bioorg Med Chem. 2015. PMID: 26088334 Free PMC article.
Synthesis of azafluorenone antimicrobial agents.
Kraus GA, Kempema A. Kraus GA, et al. Among authors: kempema a. J Nat Prod. 2010 Nov 29;73(11):1967-8. doi: 10.1021/np100536a. Epub 2010 Oct 21. J Nat Prod. 2010. PMID: 20964320
A convenient synthesis of Type A procyanidins.
Kraus GA, Yuan Y, Kempema A. Kraus GA, et al. Among authors: kempema a. Molecules. 2009 Feb 17;14(2):807-15. doi: 10.3390/molecules14020807. Molecules. 2009. PMID: 19223829 Free PMC article.
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.
Nicolaou KC, Shelke YG, Dherange BD, Kempema A, Lin B, Gu C, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. Nicolaou KC, et al. Among authors: kempema a. J Org Chem. 2020 Mar 6;85(5):2865-2917. doi: 10.1021/acs.joc.0c00123. Epub 2020 Feb 17. J Org Chem. 2020. PMID: 32065746