Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
2003 1
2012 1
2013 2
2014 1
2015 1
2016 2
2019 1
2020 1
2021 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

10 results

Results by year

Filters applied: . Clear all
Page 1
C-Peptide-based assessment of insulin secretion in the Zucker Fatty rat: a modelistic study.
Di Nardo F, Cogo CE, Faelli E, Morettini M, Burattini L, Ruggeri P. Di Nardo F, et al. PLoS One. 2015 May 4;10(5):e0125252. doi: 10.1371/journal.pone.0125252. eCollection 2015. PLoS One. 2015. PMID: 25938808 Free PMC article.
A C-peptide-based assessment of beta-cell function was performed here in the Zucker fatty rat, a suitable animal model of human metabolic syndrome. ...
A C-peptide-based assessment of beta-cell function was performed here in the Zucker fatty rat, a suitable animal model of huma …
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
Ikenoue T, Aprile FA, Sormanni P, Ruggeri FS, Perni M, Heller GT, Haas CP, Middel C, Limbocker R, Mannini B, Michaels TCT, Knowles TPJ, Dobson CM, Vendruscolo M. Ikenoue T, et al. Sci Rep. 2020 Sep 17;10(1):15280. doi: 10.1038/s41598-020-69626-3. Sci Rep. 2020. PMID: 32943652 Free PMC article.
We show that this bicyclic peptide is able to remodel the aggregation process of Abeta42 in vitro and to reduce its associated toxicity in vivo in a C. elegans worm model expressing Abeta42. These results provide an initial example of a computational approach to des …
We show that this bicyclic peptide is able to remodel the aggregation process of Abeta42 in vitro and to reduce its associated toxicity in v …
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5. Nat Commun. 2019. PMID: 30644384 Free PMC article.
This aminosterol enhances the rate of aggregation by promoting monomer-dependent secondary nucleation, but significantly reduces the toxicity of the resulting oligomers to neuroblastoma cells by inhibiting their binding to the cellular membranes. When administered to a …
This aminosterol enhances the rate of aggregation by promoting monomer-dependent secondary nucleation, but significantly reduces the toxicit …
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
Swedberg JE, Schroeder CI, Mitchell JM, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ. Swedberg JE, et al. J Biol Chem. 2016 Jul 22;291(30):15778-87. doi: 10.1074/jbc.M116.724542. Epub 2016 May 10. J Biol Chem. 2016. PMID: 27226591 Free PMC article.
These synthetic peptide hormones share the overall structure of GLP-1 and Ex-4, with a C-terminal helical segment and a flexible N-terminal tail. Although numerous studies have investigated the molecular determinants underpinning GLP-1 and Ex-4 binding and signaling …
These synthetic peptide hormones share the overall structure of GLP-1 and Ex-4, with a C-terminal helical segment and a flexib …
von Willebrand factor competes with fibrin for occupancy of GPIIb:IIIa on thrombin-stimulated platelets.
Hantgan RR, Nichols WL, Ruggeri ZM. Hantgan RR, et al. Blood. 1990 Feb 15;75(4):889-94. Blood. 1990. PMID: 2302458 Free article.
Similarly, a MoAb that recognizes the N-terminal region of vWF involved in GPIb binding did not influence fibrin binding. In contrast, a MoAb that binds to a C-terminal region of vWF involved in GPIIb:IIIa recognition caused a specific, concentration-dependent incre …
Similarly, a MoAb that recognizes the N-terminal region of vWF involved in GPIb binding did not influence fibrin binding. In contrast, a MoA …
Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency.
Shia J, Zhang L, Shike M, Guo M, Stadler Z, Xiong X, Tang LH, Vakiani E, Katabi N, Wang H, Bacares R, Ruggeri J, Boland CR, Ladanyi M, Klimstra DS. Shia J, et al. Mod Pathol. 2013 Jan;26(1):131-8. doi: 10.1038/modpathol.2012.138. Epub 2012 Aug 24. Mod Pathol. 2013. PMID: 22918162 Free PMC article.
To test our hypothesis that somatic mutation in the coding region microsatellite of the MSH6 gene might be a potential underlying mechanism for such limited MSH6 staining, we evaluated frameshift mutation in a (C)(8) tract in exon 5 of the MSH6 gene in seven tumors …
To test our hypothesis that somatic mutation in the coding region microsatellite of the MSH6 gene might be a potential underlying mechanism …
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding.
Cattaneo M, Zighetti ML, Lombardi R, Martinez C, Lecchi A, Conley PB, Ware J, Ruggeri ZM. Cattaneo M, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1978-83. doi: 10.1073/pnas.0437879100. Epub 2003 Feb 10. Proc Natl Acad Sci U S A. 2003. PMID: 12578987 Free PMC article.
Analysis of the patient's P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to …
Analysis of the patient's P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane …