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Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.
Tawbi HA, Schadendorf D, Lipson EJ, Ascierto PA, Matamala L, Castillo Gutiérrez E, Rutkowski P, Gogas HJ, Lao CD, De Menezes JJ, Dalle S, Arance A, Grob JJ, Srivastava S, Abaskharoun M, Hamilton M, Keidel S, Simonsen KL, Sobiesk AM, Li B, Hodi FS, Long GV; RELATIVITY-047 Investigators. Tawbi HA, et al. N Engl J Med. 2022 Jan 6;386(1):24-34. doi: 10.1056/NEJMoa2109970. N Engl J Med. 2022. PMID: 34986285 Free PMC article. Clinical Trial.
A noncanonical binding site of linezolid revealed via molecular dynamics simulations.
Makarov GI, Makarova TM. Makarov GI, et al. J Comput Aided Mol Des. 2020 Mar;34(3):281-291. doi: 10.1007/s10822-019-00269-x. Epub 2019 Dec 12. J Comput Aided Mol Des. 2020. PMID: 31832846
In the present study the most probable structure of the linezolid complex with a E. coli ribosome in the A,A/P,P-state that is in line with the results of biochemical studies of linezolid action has been obtained by molecular dynamics simulation methods....
In the present study the most probable structure of the linezolid complex with a E. coli ribosome in the A,A/P,P-state that is …
Intergenic HA-NA interactions in influenza A virus: postreassortment substitutions of charged amino acid in the hemagglutinin of different subtypes.
Kaverin NV, Matrosovich MN, Gambaryan AS, Rudneva IA, Shilov AA, Varich NL, Makarova NV, Kropotkina EA, Sinitsin BV. Kaverin NV, et al. Virus Res. 2000 Feb;66(2):123-9. doi: 10.1016/s0168-1702(99)00131-8. Virus Res. 2000. PMID: 10725545
More detailed studies with the use of a H3N1 reassortant and its high-yield non-aggregating variants revealed that NA of A/USSR/90/77 strain is inefficient in the removal of the terminal sialic acid residues from the virion components, and that the inefficiency of NA may be compe …
More detailed studies with the use of a H3N1 reassortant and its high-yield non-aggregating variants revealed that NA of A/USSR/90/77 strain …
A noncanonical binding site of chloramphenicol revealed via molecular dynamics simulations.
Makarov GI, Makarova TM. Makarov GI, et al. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2940-2947. doi: 10.1016/j.bbagen.2018.09.012. Epub 2018 Sep 22. Biochim Biophys Acta Gen Subj. 2018. PMID: 30248377
In the present study the putative structure of the chloramphenicol complex with a bacterial ribosome in the A,A/P,P-state has been obtained by molecular dynamics simulations methods. ...
In the present study the putative structure of the chloramphenicol complex with a bacterial ribosome in the A,A/P,P-state has …
Genetic Obesity in Pregnant Ay Mice Does Not Affect Susceptibility to Obesity and Food Choice in Offspring.
Makarova E, Dubinina A, Denisova E, Kazantseva A. Makarova E, et al. Int J Mol Sci. 2023 Mar 15;24(6):5610. doi: 10.3390/ijms24065610. Int J Mol Sci. 2023. PMID: 36982684 Free PMC article.
Metabolic parameters were assessed in pregnant and lactating A(y)/a (obesity) and a/a (control) mothers. Metabolic response to the consumption of a sweet-fat diet (SFD: SD, lard, and sweet biscuits) and the choice of components of this diet were evaluated in their m …
Metabolic parameters were assessed in pregnant and lactating A(y)/a (obesity) and a/a (control) mothers. Metabolic response to …
Pregnancy and lactation have anti-obesity and anti-diabetic effects in A(y)/a mice.
Makarova EN, Yakovleva TV, Shevchenko AY, Bazhan NM. Makarova EN, et al. Acta Physiol (Oxf). 2010 Feb;198(2):169-77. doi: 10.1111/j.1748-1716.2009.02046.x. Epub 2009 Sep 24. Acta Physiol (Oxf). 2010. PMID: 19785628
In both genotypes, concentrations of hormones increased, and glucose decreased from pregnancy day 7 to day 18 and returned to normal values after parturition. A(y)/a mice did not differ from a/a in corticosterone, insulin and glucose levels during pregnancy and lact …
In both genotypes, concentrations of hormones increased, and glucose decreased from pregnancy day 7 to day 18 and returned to normal values …
Exaggerated anorexigenic response to restraint stress in A(y) mice is associated with elevated CRFR2 mRNA expression in the hypothalamus.
Bazhan NM, Yakovleva TV, Kazantseva AY, Makarova EN. Bazhan NM, et al. Physiol Behav. 2013 Aug 15;120:19-25. doi: 10.1016/j.physbeh.2013.06.023. Epub 2013 Jul 5. Physiol Behav. 2013. PMID: 23834894
The aim of this work was to investigate mechanisms of exaggerated anorectic response to stress in A(y) mice. All parameters were measured in C57BL/6J male mice of a/a (control) and A(y)/a genotypes before, 0, 1, and 3h after a 1-h restraint. Baseline food intake and …
The aim of this work was to investigate mechanisms of exaggerated anorectic response to stress in A(y) mice. All parameters were measured in …
Novel PD-1 inhibitor prolgolimab: expanding non-resectable/metastatic melanoma therapy choice.
Tjulandin S, Demidov L, Moiseyenko V, Protsenko S, Semiglazova T, Odintsova S, Zukov R, Lazarev S, Makarova Y, Nechaeva M, Sakaeva D, Andreev A, Tarasova A, Fadeyeva N, Shustova M, Kuryshev I. Tjulandin S, et al. Eur J Cancer. 2021 May;149:222-232. doi: 10.1016/j.ejca.2021.02.030. Epub 2021 Apr 17. Eur J Cancer. 2021. PMID: 33872982 Free article. Clinical Trial.
Investigation of Allosteric Effect of 2,8-Dimethylation of A2503 in E. coli 23S rRNA by Molecular-Dynamics Simulations.
Makarova TM, Makarov GI. Makarova TM, et al. Biochemistry (Mosc). 2020 Nov;85(11):1458-1467. doi: 10.1134/S0006297920110139. Biochemistry (Mosc). 2020. PMID: 33280585
Significant alterations were detected both in the immediate environment of the 2503 23S rRNA residue and in the nucleotides located deeper in the nascent peptide exit tunnel (NPET), which are known to be involved in signal transmission from the antibiotics bound in the NPET to th …
Significant alterations were detected both in the immediate environment of the 2503 23S rRNA residue and in the nucleotides located deeper i …
32 results