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On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K. Cole MA, et al. FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21. FASEB J. 2016. PMID: 27103577 Free PMC article.
We conclude that decreased cardiac PPARalpha expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dietary fat.-Cole, M. A., Abd Jamil, A. H., Heather, L. C., Murray, A. J., Sutton, E. R., Slingo, M., Sebag-Montefiore, L., …
We conclude that decreased cardiac PPARalpha expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dieta …
Cycling cadence affects heart rate variability.
Lunt HC, Corbett J, Barwood MJ, Tipton MJ. Lunt HC, et al. Physiol Meas. 2011 Aug;32(8):1133-45. doi: 10.1088/0967-3334/32/8/009. Epub 2011 Jun 21. Physiol Meas. 2011. PMID: 21693796 Clinical Trial.
During loaded cycling (at 100 W), the low to high frequency (LF:HF) ratio formed a 'J' shaped curve as cadence increased from 40 revs min(-1) (1.4 [0.4]) to 100 revs min(-1) (1.9 [0.7]), but dipped below the 40 revs min(-1) values during the 60 revs min(-1) 1.1 (0.3 …
During loaded cycling (at 100 W), the low to high frequency (LF:HF) ratio formed a 'J' shaped curve as cadence increased from …
Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate.
Kong JY, Rabkin SW. Kong JY, et al. Arch Biochem Biophys. 2003 Apr 15;412(2):196-206. doi: 10.1016/s0003-9861(03)00008-0. Arch Biochem Biophys. 2003. PMID: 12667483
Mitochondrial potential (delta psi (m)), as demonstrated microscopically and by flow cytometry of cardiomyocytes stained with a J-aggregate dye, was markedly and significantly reduced by ceramide, palmitate, and two different inhibitors of the mitochondrial electron …
Mitochondrial potential (delta psi (m)), as demonstrated microscopically and by flow cytometry of cardiomyocytes stained with a J …