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Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Köhler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM. Mirakaj V, et al. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6555-60. doi: 10.1073/pnas.1015605108. Epub 2011 Apr 5. Proc Natl Acad Sci U S A. 2011. PMID: 21467223 Free PMC article.
Here we report that RGM-A (i) is expressed by epithelium and leukocytes (granulocytes, monocytes, and T/B lymphocytes); (ii) inhibits leukocyte migration by contact repulsion and chemorepulsion, depending on dosage, through its receptor neogenin; and (iii) suppresses the i …
Here we report that RGM-A (i) is expressed by epithelium and leukocytes (granulocytes, monocytes, and T/B lymphocytes); (ii) inhibits …
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G. Humrich JY, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):204-9. doi: 10.1073/pnas.0903158107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018660 Free PMC article.
The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In the (NZBxNZW) F(1) mouse model of lupus, we found that CD4(+)Foxp3(+) Treg failed to maintain a competitive pool size in the peripheral lymph …
The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In t …
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, et al. Allenby G, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. doi: 10.1073/pnas.90.1.30. Proc Natl Acad Sci U S A. 1993. PMID: 8380496 Free PMC article.
In contrast to the selectivity of RXRs for 9-cis-RA, RARs bind both t-RA and 9-cis-RA with high affinity, exhibiting Kd values in the 0.2-0.7 nM range for both ligands. Unlike RARs, the cellular RA binding proteins CRABPI or CRABPII bind t-RA but do not bind 9-cis-R …
In contrast to the selectivity of RXRs for 9-cis-RA, RARs bind both t-RA and 9-cis-RA with high affinity, exhibiting Kd values in the …
An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.
Gripp KW, Sol-Church K, Smpokou P, Graham GE, Stevenson DA, Hanson H, Viskochil DH, Baker LC, Russo B, Gardner N, Stabley DL, Kolbe V, Rosenberger G. Gripp KW, et al. Am J Med Genet A. 2015 Sep;167A(9):2085-97. doi: 10.1002/ajmg.a.37128. Epub 2015 Apr 25. Am J Med Genet A. 2015. PMID: 25914166 Free PMC article.
New primate genus from the Miocene of Argentina.
Tejedor MF, Tauber AA, Rosenberger AL, Swisher CC 3rd, Palacios ME. Tejedor MF, et al. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5437-41. doi: 10.1073/pnas.0506126103. Epub 2006 Mar 27. Proc Natl Acad Sci U S A. 2006. PMID: 16567649 Free PMC article.
13 results