Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.
Safi H, Gopal P, Lingaraju S, Ma S, Levine C, Dartois V, Yee M, Li L, Blanc L, Ho Liang HP, Husain S, Hoque M, Soteropoulos P, Rustad T, Sherman DR, Dick T, Alland D.
Safi H, et al.
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19665-19674. doi: 10.1073/pnas.1907631116. Epub 2019 Sep 5.
Proc Natl Acad Sci U S A. 2019.
PMID: 31488707
Free PMC article.
We have identified a mechanism of genetically encoded but rapidly reversible drug tolerance in M. tuberculosis caused by transient frameshift mutations in a homopolymeric tract (HT) of 7 cytosines (7C) in the glpK gene. ...These results suggest that GlpK phase variation ma …
We have identified a mechanism of genetically encoded but rapidly reversible drug tolerance in M. tuberculosis caused by transient fr …