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Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.
Kim GW, Siddiqui A. Kim GW, et al. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2019455118. doi: 10.1073/pnas.2019455118. Proc Natl Acad Sci U S A. 2021. PMID: 33397803 Free PMC article.
Here, we show that viral HBV X (HBx) protein is responsible for the m(6)A modifications of viral transcripts. HBV genomes defective in HBx failed to induce m(6)A modifications of HBV RNAs during infection/transfection, while ectopic expression of HBx restores m …
Here, we show that viral HBV X (HBx) protein is responsible for the m(6)A modifications of viral transcripts. HBV genomes defective i …
TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection.
Allman WR, Dey R, Liu L, Siddiqui S, Coleman AS, Bhattacharya P, Yano M, Uslu K, Takeda K, Nakhasi HL, Akkoyunlu M. Allman WR, et al. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4094-103. doi: 10.1073/pnas.1421580112. Epub 2015 Jul 13. Proc Natl Acad Sci U S A. 2015. PMID: 26170307 Free PMC article.
Transfer of WT mus to TACI KO mice was sufficient to significantly reduce disease severity. TACI is likely to influence M phenotype by mediating B cell-activating factor belonging to the TNF family (BAFF) and a proliferation inducing ligand (APRIL) signals because both the …
Transfer of WT mus to TACI KO mice was sufficient to significantly reduce disease severity. TACI is likely to influence M phenotype b …
N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle.
Imam H, Khan M, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, Kim SJ, Mason CE, Horner SM, Siddiqui A. Imam H, et al. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8829-8834. doi: 10.1073/pnas.1808319115. Epub 2018 Aug 13. Proc Natl Acad Sci U S A. 2018. PMID: 30104368 Free PMC article.
We mapped the m(6)A site in the HBV RNA and found that a conserved m(6)A consensus motif situated within the epsilon stem loop structure, is the site for m(6)A modification. The epsilon stem loop is located in the 3' terminus of all HBV mRNAs and at both the …
We mapped the m(6)A site in the HBV RNA and found that a conserved m(6)A consensus motif situated within the epsilon stem loop …
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
Kim GW, Siddiqui A. Kim GW, et al. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2022024118. doi: 10.1073/pnas.2022024118. Proc Natl Acad Sci U S A. 2021. PMID: 33649237 Free PMC article.
The HCV RNA genome is m(6)A-methylated, and this modification regulates the viral life cycle. In this study, we investigated the role of m(6)A modification of the HCV genome in the IRES-dependent translation function by mutating m(6)A consensus motifs (DRACH) …
The HCV RNA genome is m(6)A-methylated, and this modification regulates the viral life cycle. In this study, we investigated the role …
N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein.
Kim GW, Moon JS, Siddiqui A. Kim GW, et al. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2120485119. doi: 10.1073/pnas.2120485119. Proc Natl Acad Sci U S A. 2022. PMID: 35135882 Free PMC article.
Using the m(6)A site mutant in the HBV 5' epsilon, we present evidence that m(6)A methylation of 5' epsilon is necessary for its encapsidation. The m(6)A modification of 5' epsilon increased the efficiency of viral RNA packaging, whereas the m(6)A of 3 …
Using the m(6)A site mutant in the HBV 5' epsilon, we present evidence that m(6)A methylation of 5' epsilon is necessary for i …
Binding interaction of sheep alpha-2-macroglobulin and tannic acid: A spectroscopic and thermodynamic study.
Ali SS, Zia MK, Siddiqui T, Khan FH. Ali SS, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Nov 5;204:748-753. doi: 10.1016/j.saa.2018.06.024. Epub 2018 Jun 10. Spectrochim Acta A Mol Biomol Spectrosc. 2018. PMID: 30007881
An attempt has been made to study the interaction of tannic acid with alpha-2-macroglobulin (alpha(2)M). alpha(2)M is a large tetrameric glycoprotein which function as a key serum anti-proteinase under physiological conditions. ...Analysis of CD and FTIR results sug …
An attempt has been made to study the interaction of tannic acid with alpha-2-macroglobulin (alpha(2)M). alpha(2)M is a large …
Dissociating antibacterial from ototoxic effects of gentamicin C-subtypes.
O'Sullivan ME, Song Y, Greenhouse R, Lin R, Perez A, Atkinson PJ, MacDonald JP, Siddiqui Z, Lagasca D, Comstock K, Huth ME, Cheng AG, Ricci AJ. O'Sullivan ME, et al. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32423-32432. doi: 10.1073/pnas.2013065117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288712 Free PMC article.
Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano-bio interactions.
Ferdosi S, Tangeysh B, Brown TR, Everley PA, Figa M, McLean M, Elgierari EM, Zhao X, Garcia VJ, Wang T, Chang MEK, Riedesel K, Chu J, Mahoney M, Xia H, O'Brien ES, Stolarczyk C, Harris D, Platt TL, Ma P, Goldberg M, Langer R, Flory MR, Benz R, Tao W, Cuevas JC, Batzoglou S, Blume JE, Siddiqui A, Hornburg D, Farokhzad OC. Ferdosi S, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2106053119. doi: 10.1073/pnas.2106053119. Epub 2022 Mar 11. Proc Natl Acad Sci U S A. 2022. PMID: 35275789 Free PMC article.
16 results