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2004 1
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2008 1
2010 2
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2018 4
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Page 1
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Ridker PM, et al. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17. N Engl J Med. 2017. PMID: 28304242 Free article. Clinical Trial.
B cell receptors and free antibodies have different antigen-binding kinetics.
García-Sánchez M, Castro M, Faro J. García-Sánchez M, et al. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2220669120. doi: 10.1073/pnas.2220669120. Epub 2023 Aug 24. Proc Natl Acad Sci U S A. 2023. PMID: 37616223 Free PMC article.
Since the pioneering works of Berg and Purcell, discriminating between diffusion followed by binding has played a central role in understanding cell signaling. B cell receptors (BCR) and antibodies (Ab) challenge that simplified view as binding to the antigen follows after …
Since the pioneering works of Berg and Purcell, discriminating between diffusion followed by binding has played a central role in understand …
Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (-)-copalic acid.
Alves JM, Leandro LF, Senedese JM, Castro PT, Pereira DE, Resende FA, Campos DL, Silva JJMD, Varanda EA, Bastos JK, Ambrósio SR, Tavares DC. Alves JM, et al. J Toxicol Environ Health A. 2018;81(5):116-129. doi: 10.1080/15287394.2017.1420505. Epub 2017 Dec 29. J Toxicol Environ Health A. 2018. PMID: 29286884
In the in vivo test system, animals treated with CMO (6.25 mg/kg b.w.) exhibited a significant decrease in rate of MN occurrence compared to those treated only with MMS. An antigenotoxic effect of CA was noted in the MN test (1 and 2 mg/kg b.w.) and the comet assay …
In the in vivo test system, animals treated with CMO (6.25 mg/kg b.w.) exhibited a significant decrease in rate of MN occurrence comp …
Sanfilippo syndrome type B: Analysis of patients diagnosed by the MPS Brazil Network.
Montenegro YHA, de Souza CFM, Kubaski F, Trapp FB, Burin MG, Michelin-Tirelli K, Leistner-Segal S, Facchin ACB, Medeiros FS, Giugliani L, Ribeiro EM, Lourenço CM, Cardoso-Dos-Santos AC, Ribeiro MG, Kim CA, Castro MAA, Embiruçu EK, Steiner CE, Moreira MLC, Montano HQ, Baldo G, Giugliani R. Montenegro YHA, et al. Am J Med Genet A. 2022 Mar;188(3):760-767. doi: 10.1002/ajmg.a.62572. Epub 2021 Nov 22. Am J Med Genet A. 2022. PMID: 34806811
Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.
Álvarez-Fernández M, Sánchez-Martínez R, Sanz-Castillo B, Gan PP, Sanz-Flores M, Trakala M, Ruiz-Torres M, Lorca T, Castro A, Malumbres M. Álvarez-Fernández M, et al. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9. doi: 10.1073/pnas.1310745110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101512 Free PMC article.
Intriguingly, Greatwall is exported from the nucleus to the cytoplasm in a CRM1-dependent manner before NEB. This export occurs after the nuclear import of cyclin B-Cdk1 complexes, requires the kinase activity of Greatwall, and is mediated by Cdk-, but not Polo-like kinase …
Intriguingly, Greatwall is exported from the nucleus to the cytoplasm in a CRM1-dependent manner before NEB. This export occurs after the nu …
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.
Theoretical study of reaction mechanisms of OH radical with toluene 1,2-epoxide/2-methyloxepin.
Cartas-Rosado R, Castro M. Cartas-Rosado R, et al. J Phys Chem A. 2007 Dec 20;111(50):13088-98. doi: 10.1021/jp075052q. Epub 2007 Nov 29. J Phys Chem A. 2007. PMID: 18044852
The results indicated that the 2-methyloxepin, A, isomer is more stable, by 2.4 kcal/mol, than toluene 1,2-epoxide, B. Two reaction pathways were studied, RP-A and RP-B, corresponding to the reaction of OH with toluene 1,2-epoxide and 2-methyloxepin, respectively. T …
The results indicated that the 2-methyloxepin, A, isomer is more stable, by 2.4 kcal/mol, than toluene 1,2-epoxide, B. Two reaction p …
Azo-methoxy-calix[4]arene complexes with metal cations for chemical sensor applications: Characterization, QTAIM analyses and dispersion-corrected DFT- computations.
Gassoumi B, Echabaane M, Ben Mohamed FE, Nouar L, Madi F, Karayel A, Ghalla H, Castro ME, Melendez FJ, Özkınalı S, Rouis A, Ben Chaabane R. Gassoumi B, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Jan 5;264:120242. doi: 10.1016/j.saa.2021.120242. Epub 2021 Jul 30. Spectrochim Acta A Mol Biomol Spectrosc. 2022. PMID: 34358783
18 results