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Page 1
Structural insights into galanin receptor signaling.
Jiang W, Zheng S. Jiang W, et al. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2121465119. doi: 10.1073/pnas.2121465119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594396 Free PMC article.
Galanin is a biologically active neuropeptide, and functions through three distinct G protein-coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. ...Here, we report the cryoelectron microscopy structures of the GALR1-Go and the GALR2-Gq complexes bound to the endoge …
Galanin is a biologically active neuropeptide, and functions through three distinct G protein-coupled receptors (GPCRs), namely GALR1 …
A role for galanin in human and experimental inflammatory demyelination.
Wraith DC, Pope R, Butzkueven H, Holder H, Vanderplank P, Lowrey P, Day MJ, Gundlach AL, Kilpatrick TJ, Scolding N, Wynick D. Wraith DC, et al. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15466-71. doi: 10.1073/pnas.0903360106. Epub 2009 Aug 26. Proc Natl Acad Sci U S A. 2009. PMID: 19717462 Free PMC article.
Over-expression of galanin in transgenic mice (Gal-OE) abolishes disease in the EAE model, whilst loss-of-function mutations in galanin or galanin receptor-2 (GalR2) increase disease severity. ...Irrespective of the mechanism(s) by which galanin alters …
Over-expression of galanin in transgenic mice (Gal-OE) abolishes disease in the EAE model, whilst loss-of-function mutations in ga …
Galanin acts as a neuroprotective factor to the hippocampus.
Elliott-Hunt CR, Marsh B, Bacon A, Pope R, Vanderplank P, Wynick D. Elliott-Hunt CR, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5105-10. doi: 10.1073/pnas.0304823101. Epub 2004 Mar 23. Proc Natl Acad Sci U S A. 2004. PMID: 15041741 Free PMC article.
We have recently demonstrated that peripheral sensory neurons depend on galanin for neurite extension after injury, mediated by activation of the second galanin receptor subtype (GALR2). ...These results demonstrate that galanin acts an endogenous neuroprotec …
We have recently demonstrated that peripheral sensory neurons depend on galanin for neurite extension after injury, mediated by activ …
Anticonvulsant activity of a nonpeptide galanin receptor agonist.
Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. Saar K, et al. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41. doi: 10.1073/pnas.102163499. Proc Natl Acad Sci U S A. 2002. PMID: 12011470 Free PMC article.
No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesized, and screened at the rat hippocampal galanin receptor. ...These findings introduce …
No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, …
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM, Bartfai T. Lu X, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):874-9. doi: 10.1073/pnas.0408891102. Epub 2005 Jan 12. Proc Natl Acad Sci U S A. 2005. PMID: 15647369 Free PMC article.
In the present study, we demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites by 50%, in the rat dorsal raphe nucleus, where galanin coexists with serotonin. ...Direct activation of galanin receptors by a …
In the present study, we demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites …
Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.
Caramia M, Romanov RA, Sideromenos S, Hevesi Z, Zhao M, Krasniakova M, Xu ZD, Harkany T, Hökfelt TGM. Caramia M, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2222095120. doi: 10.1073/pnas.2222095120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487094 Free PMC article.
We found that NE neurons expressed at least 19 neuropeptide transcripts, notably galanin (Gal) but not Npy, and >30 neuropeptide receptors. Among the galanin receptors, Galr1 was expressed in ~19% of NE neurons, as was also confirmed by in situ hybridization. ... …
We found that NE neurons expressed at least 19 neuropeptide transcripts, notably galanin (Gal) but not Npy, and >30 neuropeptide r …
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors.
Chen Y, Song Y, Wang H, Zhang Y, Hu X, Wang K, Lu Y, Zhang Z, Li S, Li A, Bao L, Xu F, Li C, Zhang X. Chen Y, et al. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2118501119. doi: 10.1073/pnas.2118501119. Epub 2022 Aug 9. Proc Natl Acad Sci U S A. 2022. PMID: 35943985 Free PMC article.
Here, we use the type 1 herpes simplex virus H129 strain to trace the neural networks derived from two types of dorsal root ganglia (DRG) neurons: one kind of polymodal nociceptors containing galanin (Gal) and one type of pruriceptors expressing neurotensin (Nts). ...
Here, we use the type 1 herpes simplex virus H129 strain to trace the neural networks derived from two types of dorsal root ganglia (DRG) ne …
Purification of a galanin receptor from pig brain.
Chen Y, Fournier A, Couvineau A, Laburthe M, Amiranoff B. Chen Y, et al. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3845-9. doi: 10.1073/pnas.90.9.3845. Proc Natl Acad Sci U S A. 1993. PMID: 7683410 Free PMC article.
Cross-linking of a purified fraction affinity-labeled with 125I-labeled galanin revealed a single band for the galanin-receptor complex at 57 kDa. ...In contrast, unlike the CHAPS-soluble galanin receptor, binding of 125I-labeled galanin to the purifie …
Cross-linking of a purified fraction affinity-labeled with 125I-labeled galanin revealed a single band for the galanin-recepto …
Molecular cloning of a functional human galanin receptor.
Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF. Habert-Ortoli E, et al. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9780-3. doi: 10.1073/pnas.91.21.9780. Proc Natl Acad Sci U S A. 1994. PMID: 7524088 Free PMC article.
The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity (Kd in the nanomolar range) and mediates the galanin inhibition of adenylate cyclase. A 2.8-kb galanin receptor transcript was identified in sever …
The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity (Kd in the nanomolar …
Galanin: a hypothalamic-hypophysiotropic hormone modulating reproductive functions.
López FJ, Merchenthaler I, Ching M, Wisniewski MG, Negro-Vilar A. López FJ, et al. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4508-12. doi: 10.1073/pnas.88.10.4508. Proc Natl Acad Sci U S A. 1991. PMID: 1709744 Free PMC article.
Galanin (GAL) is widely distributed in the peripheral and the central nervous systems. ...To establish this, GAL and LHRH levels were measured in hypophyseal portal plasma samples using specific radioimmunoassays. Rat galanin (rGAL) concentrations in portal blood we …
Galanin (GAL) is widely distributed in the peripheral and the central nervous systems. ...To establish this, GAL and LHRH levels were …
87 results